CCL21

CCL21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L4N
Identifiers
Aliases	CCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21
External IDs	OMIM: 602737; MGI: 1349183; HomoloGene: 2247; GeneCards: CCL21; OMA:CCL21 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 34,709,005 bp[1] End 34,710,136 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 22.81 cM Start 42,772,860 bp[2] End 42,773,993 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node right lobe of thyroid gland appendix left lobe of thyroid gland rectum gallbladder gastric mucosa mucosa of transverse colon right uterine tube upper lobe of left lung Top expressed in thymus spleen urinary bladder lip ovary lung esophagus uterus colon ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity chemokine receptor binding CCR7 chemokine receptor binding chemokine activity CCR chemokine receptor binding protein binding Cellular component extracellular region extracellular space Biological process negative regulation of leukocyte tethering or rolling release of sequestered calcium ion into cytosol positive regulation of receptor-mediated endocytosis positive regulation of protein kinase B signaling positive regulation of cell motility positive regulation of actin filament polymerization monocyte chemotaxis activation of GTPase activity ruffle organization positive regulation of cell-matrix adhesion chemokine-mediated signaling pathway cellular response to tumor necrosis factor cell-cell signaling T cell costimulation cell maturation positive regulation of JNK cascade dendritic cell chemotaxis negative regulation of dendritic cell dendrite assembly positive regulation of phosphatidylinositol 3-kinase activity chemotaxis response to prostaglandin E positive regulation of dendritic cell antigen processing and presentation dendritic cell dendrite assembly positive regulation of pseudopodium assembly mesangial cell-matrix adhesion positive regulation of chemotaxis cellular response to interleukin-1 immune response establishment of T cell polarity positive regulation of ERK1 and ERK2 cascade positive regulation of glycoprotein biosynthetic process cellular response to interferon-gamma positive regulation of I-kappaB kinase/NF-kappaB signaling cell chemotaxis lymphocyte chemotaxis positive regulation of neutrophil chemotaxis positive regulation of cell adhesion mediated by integrin immunological synapse formation positive regulation of filopodium assembly positive regulation of T cell migration positive regulation of myeloid dendritic cell chemotaxis positive regulation of protein kinase activity inflammatory response antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein-coupled receptor signaling pathway negative regulation of dendritic cell apoptotic process positive regulation of T cell chemotaxis neutrophil chemotaxis chemokine (C-C motif) ligand 21 signaling pathway positive regulation of GTPase activity cellular response to chemokine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6366 18829 Ensembl ENSG00000137077 ENSMUSG00000094686 UniProt O00585 P84444 RefSeq (mRNA) NM_002989 NM_011124 RefSeq (protein) NP_002980 NP_035254 Location (UCSC) Chr 9: 34.71 – 34.71 Mb Chr 4: 42.77 – 42.77 Mb PubMed search [3] [4]
Wikidata
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Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).^[5][6][7] CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.^[8] The main function of CCL21 is to guide CCR7 expressing leukocytes to the secondary lymphoid organs, such as lymph nodes and Peyer´s patches.^[9]