CCRL1

ACKR4
Identifiers
Aliases	ACKR4, CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1, atypical chemokine receptor 4
External IDs	OMIM: 606065; MGI: 2181676; HomoloGene: 49474; GeneCards: ACKR4; OMA:ACKR4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	132,618,967 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	104,004,132 bp
RNA expression pattern
	Top expressed in
	duodenum; ; ascending aorta; ; gallbladder; ; Descending thoracic aorta; ; subcutaneous adipose tissue; ; right coronary artery; ; skin of leg; ; Achilles tendon; ; skin of abdomen; ; pituitary gland;
	Top expressed in
	lip; ; morula; ; choroid plexus of fourth ventricle; ; body of femur; ; umbilical cord; ; esophagus; ; calvaria; ; thymus; ; stroma of bone marrow; ; zone of skin;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; chemokine binding; scavenger receptor activity; G protein-coupled receptor activity; protein binding; chemokine receptor activity; C-C chemokine receptor activity; C-C chemokine binding;
Cellular component	recycling endosome; plasma membrane; membrane; endosome; integral component of membrane; early endosome; integral component of plasma membrane; external side of plasma membrane;
Biological process	receptor-mediated endocytosis; signal transduction; immune response; chemotaxis; G protein-coupled receptor signaling pathway; chemokine-mediated signaling pathway; positive regulation of cytosolic calcium ion concentration; calcium-mediated signaling; cell chemotaxis; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	51554
	252837
	ENSG00000129048
	ENSMUSG00000079355
	Q9NPB9
	Q924I3
	NM_178445; NM_016557
	NM_145700
	NP_057641; NP_848540
	NP_663746
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.^[5]^[6]

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129048 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V (May 2000). "Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart". Gene. 246 (1–2): 229–38. doi:10.1016/S0378-1119(00)00076-7. PMID 10767544.
^ ^a ^b "Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129048 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079355 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10767544-5] Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V (May 2000). "Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart". Gene. 246 (1–2): 229–38. doi:10.1016/S0378-1119(00)00076-7. PMID 10767544.

[entrez-6] "Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1".

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