CCRL2

CCRL2
Identifiers
Aliases	CCRL2, ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR, C-C motif chemokine receptor like 2
External IDs	OMIM: 608379; MGI: 1920904; HomoloGene: 2948; GeneCards: CCRL2; OMA:CCRL2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,412,997 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	110,886,587 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; upper lobe of left lung; ; mucosa of sigmoid colon; ; appendix; ; monocyte; ; right lung; ; granulocyte; ; spleen; ; bone marrow cells;
	Top expressed in
	granulocyte; ; right lung lobe; ; embryo; ; muscle of thigh; ; stroma of bone marrow; ; triceps brachii muscle; ; vastus lateralis muscle; ; digastric muscle; ; left lung; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; chemokine receptor activity; signal transducer activity; CCR chemokine receptor binding; chemokine receptor binding; C-C chemokine receptor activity; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cytoplasm; external side of plasma membrane;
Biological process	chemotaxis; G protein-coupled receptor signaling pathway; signal transduction; chemokine-mediated signaling pathway; inflammatory response; immune response; positive regulation of cytosolic calcium ion concentration; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	9034
	54199
	ENSG00000121797
	ENSMUSG00000043953
	O00421
	O35457
	NM_001130910; NM_003965
	NM_017466; NM_001302376; NM_001302377
	NP_001124382; NP_003956
	NP_001289305; NP_001289306; NP_059494
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.^[5]^[6] Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121797 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043953 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y (Mar 1998). "Cloning and characterization of a novel human chemokine receptor". Biochem Biophys Res Commun. 243 (1): 264–8. doi:10.1006/bbrc.1997.7981. PMID 9473515.
^ "Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2".
^ Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC (September 2008). "Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis". J. Exp. Med. 205 (10): 2207–20. doi:10.1084/jem.20080300. PMC 2556791. PMID 18794339.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121797 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043953 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9473515-5] Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y (Mar 1998). "Cloning and characterization of a novel human chemokine receptor". Biochem Biophys Res Commun. 243 (1): 264–8. doi:10.1006/bbrc.1997.7981. PMID 9473515.

[entrez-6] "Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2".

[pmid18794339-7] Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC (September 2008). "Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis". J. Exp. Med. 205 (10): 2207–20. doi:10.1084/jem.20080300. PMC 2556791. PMID 18794339.

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