CD155

PVR
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4FQP, 1DGI, 1NN8, 3EPC, 3EPD, 3EPF, 3J8F, 3J9F, 3UDW, 3URO
Identifiers
Aliases	PVR, CD155, HVED, NECL5, Necl-5, PVS, TAGE4, poliovirus receptor, PVR cell adhesion molecule
External IDs	OMIM: 173850; HomoloGene: 9672; GeneCards: PVR; OMA:PVR - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,666,162 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; islet of Langerhans; ; tendon of biceps brachii; ; left ventricle; ; apex of heart; ; right lobe of liver; ; upper lobe of left lung; ; anterior pituitary; ; left adrenal gland; ; right auricle;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; virus receptor activity; protein binding; signaling receptor binding; cell adhesion molecule binding; signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; focal adhesion; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; extracellular exosome; extracellular space;
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; cell recognition; susceptibility to natural killer cell mediated cytotoxicity; cell adhesion; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; regulation of immune response; viral entry into host cell; susceptibility to T cell mediated cytotoxicity; viral process; adherens junction organization; positive regulation of natural killer cell mediated cytotoxicity; homophilic cell adhesion via plasma membrane adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	5817
	n/a
	ENSG00000073008
	n/a
	P15151
	n/a
	NM_001135768; NM_001135769; NM_001135770; NM_006505
	n/a
	NP_001129240; NP_001129241; NP_001129242; NP_006496
	n/a
	Wikidata
View/Edit Human

CD155 (cluster of differentiation 155), also known as the poliovirus receptor, is a protein that in humans is encoded by the PVR gene.^[3]^[4] It is a transmembrane protein that is involved in forming junctions between neighboring cells. It is also the molecule that poliovirus uses to enter cells. The gene is specific to the primates.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073008 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: poliovirus receptor".
^ Koike S, Horie H, Ise I, Okitsu A, Yoshida M, Iizuka N, Takeuchi K, Takegami T, Nomoto A (October 1990). "The poliovirus receptor protein is produced both as membrane-bound and secreted forms". EMBO J. 9 (10): 3217–24. doi:10.1002/j.1460-2075.1990.tb07520.x. PMC 552052. PMID 2170108.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073008 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: poliovirus receptor".

[pmid2170108-4] Koike S, Horie H, Ise I, Okitsu A, Yoshida M, Iizuka N, Takeuchi K, Takegami T, Nomoto A (October 1990). "The poliovirus receptor protein is produced both as membrane-bound and secreted forms". EMBO J. 9 (10): 3217–24. doi:10.1002/j.1460-2075.1990.tb07520.x. PMC 552052. PMID 2170108.

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