CD1D

CD1D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WO4, 1ZT4, 2PO6, 3HUJ, 3SDX, 3TZV, 3U0P, 3VWJ, 3VWK, 4EN3, 4LHU, 4MNG, 4MQ7, 4WW2
Identifiers
Aliases	CD1D, CD1A, R3, R3G1, CD1d molecule
External IDs	OMIM: 188410; MGI: 107674; HomoloGene: 1337; GeneCards: CD1D; OMA:CD1D - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 158,178,030 bp[1] End 158,186,427 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 37.91 cM Start 86,903,141 bp[2] End 86,906,748 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte thymus spleen blood gonad right lobe of liver appendix jejunal mucosa duodenum Top expressed in white adipose tissue left lobe of liver subcutaneous adipose tissue brown adipose tissue tunica adventitia of aorta intercostal muscle body of femur lactiferous gland fossa Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-2-microglobulin binding lipopeptide binding histone binding endogenous lipid antigen binding lipid antigen binding exogenous lipid antigen binding cell adhesion molecule binding protein binding Cellular component cytoplasm integral component of membrane endosome endoplasmic reticulum membrane membrane integral component of plasma membrane cell surface lysosomal membrane basolateral plasma membrane lysosome endosome membrane plasma membrane endoplasmic reticulum extracellular space external side of plasma membrane Biological process immune system process T cell selection heterotypic cell-cell adhesion positive regulation of T cell proliferation detection of bacterium positive regulation of innate immune response antigen processing and presentation, exogenous lipid antigen via MHC class Ib innate immune response viral process antigen processing and presentation, endogenous lipid antigen via MHC class Ib regulation of immune response positive regulation of T cell mediated cytotoxicity immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 912 12479 Ensembl ENSG00000158473 ENSMUSG00000028076 UniProt P15813 P11609 RefSeq (mRNA) NM_001766 NM_001319145 NM_001371761 NM_001371762 NM_001371763 NM_007639 NM_001379501 NM_001379502 NM_001379503 RefSeq (protein) NP_001306074 NP_001757 NP_001358690 NP_001358691 NP_001358692 NP_031665 NP_001366430 NP_001366431 NP_001366432 Location (UCSC) Chr 1: 158.18 – 158.19 Mb Chr 3: 86.9 – 86.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD1D is the human gene that encodes the protein CD1d,^[5] a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to the class I MHC proteins, and are involved in the presentation of lipid antigens to T cells. CD1d is the only member of the group 2 CD1 molecules.