CD200R1

CD200R1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD200R1, CD200R, HCRTR2, MOX2R, OX2R, CD200 receptor 1
External IDsOMIM: 607546; MGI: 1889024; HomoloGene: 10957; GeneCards: CD200R1; OMA:CD200R1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

131450

57781

Ensembl

ENSG00000163606

ENSMUSG00000022667

UniProt

Q8TD46

Q9ES57

RefSeq (mRNA)

NM_138806
NM_138939
NM_138940
NM_170780

NM_021325

RefSeq (protein)

NP_620161
NP_620385
NP_620386
NP_740750

NP_067300

Location (UCSC)Chr 3: 112.92 – 112.98 MbChr 16: 44.59 – 44.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.[5][6][7] CD200R1 is expressed on the surface of myeloid cells[8] and CD4+ T cells.[9] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,[10] epithelial cells,[11] endothelial cells,[12] fibroblasts,[13] and lymphoid cells.[14]

CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha),[15] interferons, and inducible nitric oxide synthase (iNOS).[16]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163606 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022667 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/S1074-7613(00)00023-6. PMID 10981966.
  6. ^ Dick AD, Broderick C, Forrester JV, Wright GJ (January 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Investigative Ophthalmology & Visual Science. 42 (1): 170–6. PMID 11133863.
  7. ^ "Entrez Gene: CD200R1 CD200 receptor 1".
  8. ^ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (August 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. doi:10.1016/s1074-7613(00)00023-6. PMID 10981966.
  9. ^ Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R (2012). "Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells". PLOS ONE. 7 (4): e35466. Bibcode:2012PLoSO...735466C. doi:10.1371/journal.pone.0035466. PMC 3322173. PMID 22496920.
  10. ^ Costello DA, Lyons A, Denieffe S, Browne TC, Cox FF, Lynch MA (October 2011). "Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation". The Journal of Biological Chemistry. 286 (40): 34722–32. doi:10.1074/jbc.M111.280826. PMC 3186410. PMID 21835925.
  11. ^ Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL (November 2004). "Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?". The Journal of Investigative Dermatology. 123 (5): 880–7. doi:10.1111/j.0022-202X.2004.23461.x. PMID 15482475.
  12. ^ Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH (January 2009). "Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions". Journal of Anatomy. 214 (1): 183–95. doi:10.1111/j.1469-7580.2008.00986.x. PMC 2667927. PMID 19166481.
  13. ^ Ishibashi M, Neri S, Hashimoto H, Miyashita T, Yoshida T, Nakamura Y, Udagawa H, Kirita K, Matsumoto S, Umemura S, Yoh K, Niho S, Tsuboi M, Masutomi K, Goto K, Ochiai A, Ishii G (April 2017). "CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors". Scientific Reports. 7: 46662. Bibcode:2017NatSR...746662I. doi:10.1038/srep46662. PMC 5399371. PMID 28429795.
  14. ^ Gentry M, Bodo J, Durkin L, Hsi ED (February 2017). "Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma". The American Journal of Surgical Pathology. 41 (2): 189–194. doi:10.1097/PAS.0000000000000771. PMID 27879516. S2CID 25206581.
  15. ^ Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P (2012). "CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells". PLOS ONE. 7 (2): e31671. Bibcode:2012PLoSO...731671P. doi:10.1371/journal.pone.0031671. PMC 3282758. PMID 22363701.
  16. ^ Carter DA, Dick AD (June 2004). "CD200 maintains microglial potential to migrate in adult human retinal explant model". Current Eye Research. 28 (6): 427–36. doi:10.1080/02713680490503778. PMID 15512951. S2CID 20846500.