CD23

FCER2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N, 4J6P, 4J6Q
Identifiers
Aliases	FCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II
External IDs	OMIM: 151445; MGI: 95497; HomoloGene: 1517; GeneCards: FCER2; OMA:FCER2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 7,688,758 bp[1] End 7,702,146 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 1.92 cM Start 3,731,737 bp[2] End 3,744,175 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle granulocyte spleen lymph node appendix blood monocyte mucosa of transverse colon bone marrow cells tonsil Top expressed in mesenteric lymph nodes spleen blood subcutaneous adipose tissue granulocyte embryo thymus tibiofemoral joint white adipose tissue morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function IgE binding integrin binding protein binding metal ion binding carbohydrate binding Cellular component integral component of membrane extracellular region plasma membrane integral component of plasma membrane extracellular exosome external side of plasma membrane membrane Biological process Notch signaling pathway positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of nitric-oxide synthase activity positive regulation of killing of cells of other organism positive regulation of nitric-oxide synthase biosynthetic process cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2208 14128 Ensembl ENSG00000104921 ENSMUSG00000005540 UniProt P06734 P20693 RefSeq (mRNA) NM_001207019 NM_001220500 NM_002002 NM_001253737 NM_001253739 NM_001253743 NM_001253745 NM_001253746 NM_001253747 NM_013517 RefSeq (protein) NP_001193948 NP_001207429 NP_001993 NP_001240666 NP_001240668 NP_001240672 NP_001240674 NP_001240675 NP_001240676 NP_038545 Location (UCSC) Chr 19: 7.69 – 7.7 Mb Chr 8: 3.73 – 3.74 Mb PubMed search [3] [4]
Wikidata
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CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.

There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages.^[5]