Protein found in humans
CD244 (Cluster of Differentiation 244) also known as 2B4 or SLAMF4 is a protein that in humans is encoded by the CD244 gene.[5]
CD244 is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule family of receptors (SLAMF) which are expressed in different types of hematopoietic cells.[6] CD244 plays a role in the regulation of the immune system.[7]
A ligand of CD244 is CD48 (SLAMF2). CD48 also belongs to the SLAMF, it does not have an intracellular domain and it is anchored to the plasma membrane by a GPI-anchor.[6] Only these two receptors from the SLAMF mediate heterophilic interactions.[8][7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000122223 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004709 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: CD244 CD244 molecule, natural killer cell receptor 2B4".
- ^ a b Pahima H, Puzzovio PG, Levi-Schaffer F (July 2019). "2B4 and CD48: A powerful couple of the immune system". Clinical Immunology. 204: 64–68. doi:10.1016/j.clim.2018.10.014. PMID 30366105. S2CID 53091716.
- ^ a b Sun L, Gang X, Li Z, Zhao X, Zhou T, Zhang S, Wang G (2021). "Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases". Frontiers in Immunology. 12: 648182. doi:10.3389/fimmu.2021.648182. PMC 8024546. PMID 33841431.
- ^ van Driel BJ, Liao G, Engel P, Terhorst C (2016). "Responses to Microbial Challenges by SLAMF Receptors". Frontiers in Immunology. 7: 4. doi:10.3389/fimmu.2016.00004. PMC 4718992. PMID 26834746.
