CD27

CD27
Identifiers
Aliases	CD27, S152, S152. LPFS2, T14, TNFRSF7, Tp55, CD27 molecule
External IDs	OMIM: 186711; MGI: 88326; HomoloGene: 74386; GeneCards: CD27; OMA:CD27 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,451,718 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,213,973 bp
RNA expression pattern
	Top expressed in
	lymph node; ; spleen; ; appendix; ; bone marrow cells; ; granulocyte; ; blood; ; duodenum; ; testicle; ; mucosa of transverse colon; ; tonsil;
	Top expressed in
	thymus; ; spleen; ; epithelium of small intestine; ; intestinal villus; ; Ileal epithelium; ; pharynx; ; granulocyte; ; bone marrow; ; spermatid; ; neck;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	tumor necrosis factor-activated receptor activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; transmembrane signaling receptor activity;
Cellular component	extracellular region; integral component of membrane; integral component of plasma membrane; membrane; cell surface; plasma membrane; external side of plasma membrane;
Biological process	negative regulation of apoptotic process; response to lipopolysaccharide; response to ethanol; negative regulation of T cell apoptotic process; extrinsic apoptotic signaling pathway; regulation of cell population proliferation; cell surface receptor signaling pathway; apoptotic process; tumor necrosis factor-mediated signaling pathway; immunoglobulin mediated immune response; positive regulation of JNK cascade; inflammatory response; immune response; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of B cell differentiation; positive regulation of T cell differentiation; multicellular organism development; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	939
	21940
	ENSG00000139193
	ENSMUSG00000030336
	P26842
	P41272
	NM_001242
	NM_001033126; NM_001042564; NM_001286753
	NP_001233
	NP_001028298; NP_001036029; NP_001273682
	Wikidata
View/Edit Human	View/Edit Mouse

CD27 is a member of the tumor necrosis factor receptor superfamily.^[5] It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139193 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030336 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Buchan SL, Rogel A, Al-Shamkhani A (January 2018). "The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy". Blood. 131 (1): 39–48. doi:10.1182/blood-2017-07-741025. PMID 29118006.
^ Sturgill ER (November 2017). "TNFR agonists: a review of current biologics targeting OX40, 4-1BB, CD27, and GITR". American Journal of Hematology/Oncology. 13 (11): 4–15.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139193 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030336 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Buchan_2018-5] Buchan SL, Rogel A, Al-Shamkhani A (January 2018). "The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy". Blood. 131 (1): 39–48. doi:10.1182/blood-2017-07-741025. PMID 29118006.

[Sturgill_2017-6] Sturgill ER (November 2017). "TNFR agonists: a review of current biologics targeting OX40, 4-1BB, CD27, and GITR". American Journal of Hematology/Oncology. 13 (11): 4–15.

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