CD2AP

CD2AP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FEI, 2J6F, 2J6K, 2J6O, 2J7I, 3AA6, 3LK4, 3U23, 4WCI, 4X1V
Identifiers
Aliases	CD2AP, CMS, CD2-associated protein, CD2 associated protein
External IDs	OMIM: 604241; MGI: 1330281; HomoloGene: 7663; GeneCards: CD2AP; OMA:CD2AP - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	47,627,263 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,187,556 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of colon; ; mucosa of sigmoid colon; ; duodenum; ; rectum; ; glomerulus; ; amniotic fluid; ; metanephric glomerulus; ; oral cavity; ; germinal epithelium;
	Top expressed in
	gastrula; ; gastric mucosa; ; mucous cell of stomach; ; renal corpuscle; ; epithelium of stomach; ; medullary collecting duct; ; urothelium; ; decidua; ; aortic valve; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	beta-catenin binding; SH3 domain binding; protein-containing complex binding; structural constituent of cytoskeleton; protein C-terminus binding; protein binding; vascular endothelial growth factor receptor binding; cadherin binding;
Cellular component	filamentous actin; cell projection; cell-cell junction; ruffle; endocytic vesicle; cell leading edge; actin cytoskeleton; perinuclear region of cytoplasm; extracellular exosome; cytoskeleton; cytoplasm; plasma membrane; cell junction; protein-containing complex;
Biological process	regulation of actin cytoskeleton reorganization; negative regulation of transforming growth factor beta1 production; vesicle organization; substrate-dependent cell migration, cell extension; cell division; cell cycle; cell migration; regulation of receptor-mediated endocytosis; signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of protein localization to nucleus; actin filament organization; negative regulation of small GTPase mediated signal transduction; cell-cell adhesion; protein-containing complex assembly; positive regulation of protein secretion;
	Sources:Amigo / QuickGO
Orthologs
	23607
	12488
	ENSG00000198087
	ENSMUSG00000061665
	Q9Y5K6
	Q9JLQ0
	NM_012120
	NM_009847
	NP_036252
	NP_033977
	Wikidata
View/Edit Human	View/Edit Mouse

CD2-associated protein is a protein that in humans is encoded by the CD2AP gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198087 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061665 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H (Jun 1999). "CMS: An adapter molecule involved in cytoskeletal rearrangements". Proc Natl Acad Sci USA. 96 (11): 6211–6. Bibcode:1999PNAS...96.6211K. doi:10.1073/pnas.96.11.6211. PMC 26861. PMID 10339567.
^ "Entrez Gene: CD2AP CD2-associated protein".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198087 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061665 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10339567-5] Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H (Jun 1999). "CMS: An adapter molecule involved in cytoskeletal rearrangements". Proc Natl Acad Sci USA. 96 (11): 6211–6. Bibcode:1999PNAS...96.6211K. doi:10.1073/pnas.96.11.6211. PMC 26861. PMID 10339567.

[entrez-6] "Entrez Gene: CD2AP CD2-associated protein".

[1]

[2]

[3]

[4]

[5]

[6]