CD36

CD36
Identifiers
AliasesCD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, CD36 molecule
External IDsOMIM: 173510; MGI: 107899; HomoloGene: 73871; GeneCards: CD36; OMA:CD36 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

948

12491

Ensembl

ENSG00000135218

ENSMUSG00000002944

UniProt

P16671

Q08857

RefSeq (mRNA)

NM_001159555
NM_001159556
NM_001159557
NM_001159558
NM_007643

RefSeq (protein)

NP_001153027
NP_001153028
NP_001153029
NP_001153030
NP_031669

Location (UCSC)Chr 7: 80.37 – 80.68 MbChr 5: 17.99 – 18.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface of many cell types in vertebrate animals. It imports fatty acids inside cells and is a member of the class B scavenger receptor family of cell surface proteins. CD36 binds many ligands including collagen,[5] thrombospondin,[6] erythrocytes parasitized with Plasmodium falciparum,[7] oxidized low density lipoprotein,[8][9] native lipoproteins,[10] oxidized phospholipids,[11] and long-chain fatty acids.[12]

Work in genetically modified rodents suggest a role for CD36 in fatty acid metabolism,[13][14][15] heart disease,[16] taste,[17][18][19] and dietary fat processing in the intestine.[20] It may be involved in glucose intolerance, atherosclerosis, arterial hypertension, diabetes, cardiomyopathy, Alzheimer's disease and various cancers, mostly of epithelial origin (breast, prostate, ovary, and colon) and also for hepatic carcinoma and gliomas.[21][22][23]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135218 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002944 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tandon NN, Kralisz U, Jamieson GA (May 1989). "Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion". The Journal of Biological Chemistry. 264 (13): 7576–83. doi:10.1016/S0021-9258(18)83273-2. PMID 2468670.
  6. ^ Silverstein RL, Baird M, Lo SK, Yesner LM (August 1992). "Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor". The Journal of Biological Chemistry. 267 (23): 16607–12. doi:10.1016/S0021-9258(18)42046-7. PMID 1379600.
  7. ^ Oquendo P, Hundt E, Lawler J, Seed B (July 1989). "CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes". Cell. 58 (1): 95–101. doi:10.1016/0092-8674(89)90406-6. PMID 2473841. S2CID 22059108.
  8. ^ Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA (June 1993). "CD36 is a receptor for oxidized low density lipoprotein". The Journal of Biological Chemistry. 268 (16): 11811–6. doi:10.1016/S0021-9258(19)50272-1. PMID 7685021.
  9. ^ Nicholson AC, Frieda S, Pearce A, Silverstein RL (February 1995). "Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site". Arteriosclerosis, Thrombosis, and Vascular Biology. 15 (2): 269–75. doi:10.1161/01.ATV.15.2.269. PMID 7538425.
  10. ^ Calvo D, Gómez-Coronado D, Suárez Y, Lasunción MA, Vega MA (April 1998). "Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL". Journal of Lipid Research. 39 (4): 777–88. doi:10.1016/S0022-2275(20)32566-9. PMID 9555943.[permanent dead link‍]
  11. ^ Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, et al. (October 2002). "Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36". The Journal of Biological Chemistry. 277 (41): 38503–16. doi:10.1074/jbc.M203318200. PMID 12105195.
  12. ^ Baillie AG, Coburn CT, Abumrad NA (September 1996). "Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog". The Journal of Membrane Biology. 153 (1): 75–81. doi:10.1007/s002329900111. PMID 8694909. S2CID 5911289.
  13. ^ Hajri T, Han XX, Bonen A, Abumrad NA (May 2002). "Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice". The Journal of Clinical Investigation. 109 (10): 1381–9. doi:10.1172/JCI14596. PMC 150975. PMID 12021254.
  14. ^ Pravenec M, Landa V, Zídek V, Musilová A, Kazdová L, Qi N, et al. (2003). "Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension" (PDF). Physiological Research. 52 (6): 681–8. doi:10.33549/physiolres.930380. PMID 14640889.
  15. ^ Mistry JJ, Bowles KM, Rushworth SA (December 2021). "Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection". Nature Communications. 12 (1): 7130. Bibcode:2021NatCo..12.7130M. doi:10.1038/s41467-021-27460-9. PMC 8655073. PMID 34880245.
  16. ^ Febbraio M, Podrez EA, Smith JD, Hajjar DP, Hazen SL, Hoff HF, et al. (April 2000). "Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice". The Journal of Clinical Investigation. 105 (8): 1049–56. doi:10.1172/JCI9259. PMC 300837. PMID 10772649.
  17. ^ Laugerette F, Passilly-Degrace P, Patris B, Niot I, Febbraio M, Montmayeur JP, Besnard P (November 2005). "CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions". The Journal of Clinical Investigation. 115 (11): 3177–84. doi:10.1172/JCI25299. PMC 1265871. PMID 16276419.
  18. ^ Pepino MY, Love-Gregory L, Klein S, Abumrad NA (March 2012). "The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects". Journal of Lipid Research. 53 (3): 561–6. doi:10.1194/jlr.M021873. PMC 3276480. PMID 22210925.
  19. ^ DiPatrizio NV (September 2014). "Is fat taste ready for primetime?". Physiology & Behavior. 136: 145–54. doi:10.1016/j.physbeh.2014.03.002. PMC 4162865. PMID 24631296.
  20. ^ Drover VA, Ajmal M, Nassir F, Davidson NO, Nauli AM, Sahoo D, et al. (May 2005). "CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood". The Journal of Clinical Investigation. 115 (5): 1290–7. doi:10.1172/JCI21514. PMC 1074677. PMID 15841205.
  21. ^ Rać ME, Safranow K, Poncyljusz W (2007). "Molecular basis of human CD36 gene mutations". Molecular Medicine. 13 (5–6): 288–96. doi:10.2119/2006-00088.Rac. PMC 1936231. PMID 17673938.
  22. ^ Ana-Maria Enciu, Eugen Radu, Ionela Daniela Popescu, Mihail Eugen Hinescu, Laura Cristina Ceafalan (2018). "Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?". BioMed Research International. 2018: 1–12. doi:10.1155/2018/7801202. PMC 6057354. PMID 30069479.
  23. ^ Jingchun Wang, Yongsheng Li (2019). "CD36 tango in cancer: signaling pathways and functions". Theranostics. 9 (17): 4893–490. doi:10.7150/thno.36037. PMC 6691380. PMID 31410189.