CD40 (protein)

CD40
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule
External IDsOMIM: 109535; MGI: 88336; HomoloGene: 954; GeneCards: CD40; OMA:CD40 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011611
NM_170702
NM_170703
NM_170704

RefSeq (protein)

NP_035741
NP_733803
NP_733804
NP_733805

Location (UCSC)Chr 20: 46.12 – 46.13 MbChr 2: 164.9 – 164.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.

Activated CD4+ T cells primarily exhibit its ligand CD40L/CD154 to antigen-presenting cells including dendritic cells (DCs), B cells, macrophages, classical and non-classical monocytes, on a variety of non-immune cells including platelets and endothelial cells, and on several types of tumor cells.[5]

Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101017Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017652Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Salomon R, Dahan R (2022). "Next Generation CD40 Agonistic Antibodies for Cancer Immunotherapy". Frontiers in Immunology. 13: 940674. doi:10.3389/fimmu.2022.940674. PMC 9326085. PMID 35911742.