CD6

CD6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A2E
Identifiers
Aliases	CD6, TP120, CD6 molecule
External IDs	OMIM: 186720; MGI: 103566; HomoloGene: 4893; GeneCards: CD6; OMA:CD6 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	61,020,377 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,807,422 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; blood; ; thymus; ; appendix; ; spleen; ; cervix epithelium; ; superficial temporal artery; ; bone marrow; ; endothelial cell;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; blood; ; granulocyte; ; embryo; ; axillary lymph node; ; subcutaneous adipose tissue; ; embryo; ; spleen; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipopolysaccharide binding; lipoteichoic acid binding; scavenger receptor activity; protein binding; identical protein binding;
Cellular component	integral component of membrane; membrane; intrinsic component of plasma membrane; plasma membrane; integral component of plasma membrane; T cell receptor complex; extracellular region; immunological synapse; external side of plasma membrane;
Biological process	positive regulation of cytokine production involved in inflammatory response; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; adaptive immune response; immune system process; acute inflammatory response to antigenic stimulus; receptor-mediated endocytosis; response to lipopolysaccharide; cell adhesion; positive regulation of T cell proliferation; innate immune response; immunological synapse formation; lipopolysaccharide-mediated signaling pathway; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	923
	12511
	ENSG00000013725
	ENSMUSG00000024670
	P30203
	Q61003
	NM_001254750; NM_001254751; NM_006725
	NM_001037801; NM_009852
	NP_001241679; NP_001241680; NP_006716
	NP_001032890; NP_033982
	Wikidata
View/Edit Human	View/Edit Mouse

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013725 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024670 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD6 CD6 molecule".
^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000013725 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024670 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD6 CD6 molecule".

[pmid7760007-6] Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.

[1]

[2]

[3]

[4]

[5]

[6]