CD79A

CD79A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CV9
Identifiers
Aliases	CD79A, IGA, MB-1, CD79a molecule, MB1, IGAlpha
External IDs	OMIM: 112205; MGI: 101774; HomoloGene: 31053; GeneCards: CD79A; OMA:CD79A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,881,372 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,601,622 bp
RNA expression pattern
	Top expressed in
	spleen; ; granulocyte; ; lymph node; ; appendix; ; bone marrow cells; ; blood; ; mucosa of ileum; ; mucosa of transverse colon; ; rectum; ; epithelium of colon;
	Top expressed in
	spleen; ; bone marrow; ; granulocyte; ; thymus; ; colon; ; jejunum; ; ileum; ; lung; ; duodenum; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; protein homodimerization activity;
Cellular component	integral component of membrane; multivesicular body; membrane raft; plasma membrane; membrane; external side of plasma membrane; cytoplasm; B cell receptor complex; integral component of plasma membrane;
Biological process	B cell activation; B cell proliferation; cell surface receptor signaling pathway; adaptive immune response; immune system process; B cell differentiation; B cell receptor signaling pathway; protein homotetramerization;
	Sources:Amigo / QuickGO
Orthologs
	973
	12518
	ENSG00000105369
	ENSMUSG00000003379
	P11912
	P11911
	NM_021601; NM_001783
	NM_007655
	NP_001774; NP_067612
	NP_031681
	Wikidata
View/Edit Human	View/Edit Mouse

Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene.^[5]

The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR). This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface.^[6]

It is associated with agammaglobulinemia-3.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105369 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003379 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD79A CD79a molecule, immunoglobulin-associated alpha".
^ Leong AS, Cooper K, Leong FJ (2003). Manual of Diagnostic Cytology (2nd ed.). Greenwich Medical Media, Ltd. pp. XX. ISBN 1-84110-100-1.
^ Online Mendelian Inheritance in Man (OMIM): 613501

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105369 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003379 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD79A CD79a molecule, immunoglobulin-associated alpha".

[Leong-6] Leong AS, Cooper K, Leong FJ (2003). Manual of Diagnostic Cytology (2nd ed.). Greenwich Medical Media, Ltd. pp. XX. ISBN 1-84110-100-1.

[omim.org-7] Online Mendelian Inheritance in Man (OMIM): 613501

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