CD79A

CD79A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD79A, IGA, MB-1, CD79a molecule, MB1, IGAlpha
External IDsOMIM: 112205; MGI: 101774; HomoloGene: 31053; GeneCards: CD79A; OMA:CD79A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021601
NM_001783

NM_007655

RefSeq (protein)

NP_001774
NP_067612

NP_031681

Location (UCSC)Chr 19: 41.88 – 41.88 MbChr 7: 24.6 – 24.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene.[5]

The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR). This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface.[6]

It is associated with agammaglobulinemia-3.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105369Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003379Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CD79A CD79a molecule, immunoglobulin-associated alpha".
  6. ^ Leong AS, Cooper K, Leong FJ (2003). Manual of Diagnostic Cytology (2nd ed.). Greenwich Medical Media, Ltd. pp. XX. ISBN 1-84110-100-1.
  7. ^ Online Mendelian Inheritance in Man (OMIM): 613501