CD79B

CD79B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KG5
Identifiers
Aliases	CD79B, AGM6, B29, IGB, CD79b molecule, Igbeta
External IDs	OMIM: 147245; MGI: 96431; HomoloGene: 521; GeneCards: CD79B; OMA:CD79B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,932,336 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,205,588 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; lymph node; ; appendix; ; apex of heart; ; blood; ; monocyte; ; gonad; ; bone marrow; ; anterior pituitary;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; tibiofemoral joint; ; blood; ; bone marrow; ; granulocyte; ; submandibular gland; ; thymus; ; subcutaneous adipose tissue; ; tunica adventitia of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; protein homodimerization activity; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; Golgi apparatus; integral component of plasma membrane; extracellular exosome; membrane; nucleoplasm; external side of plasma membrane; B cell receptor complex; cytoplasm; cytosol;
Biological process	cell surface receptor signaling pathway; adaptive immune response; immune response; signal transduction; immune system process; B cell differentiation; B cell receptor signaling pathway; protein homooligomerization; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	974
	15985
	ENSG00000007312
	ENSMUSG00000040592
	P40259
	P15530
	NM_000626; NM_001039933; NM_021602; NM_001329050
	NM_008339; NM_001313939
	NP_000617; NP_001035022; NP_001315979; NP_067613
	NP_001300868; NP_032365
	Wikidata
View/Edit Human	View/Edit Mouse

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.^[5]

It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007312 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040592 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007312 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040592 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta".

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