CD8A

CD8A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AKJ, 1CD8, 1Q69, 2HP4, 3QZW
Identifiers
Aliases	CD8A, CD8, Leu2, MAL, p32, CD8a molecule
External IDs	OMIM: 186910; MGI: 88346; HomoloGene: 133777; GeneCards: CD8A; OMA:CD8A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	86,808,396 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	71,356,157 bp
RNA expression pattern
	Top expressed in
	thymus; ; spleen; ; granulocyte; ; blood; ; superficial temporal artery; ; lymph node; ; jejunal mucosa; ; appendix; ; bone marrow; ; bone marrow cells;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; blood; ; spleen; ; subcutaneous adipose tissue; ; duodenum; ; embryo; ; jejunum; ; sternocleidomastoid muscle; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	coreceptor activity; protein binding; MHC class I protein binding; protein kinase binding; MHC class I protein complex binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; T cell receptor complex; extracellular region; plasma membrane raft; external side of plasma membrane;
Biological process	antigen processing and presentation; adaptive immune response; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; immune response; regulation of immune response; T cell activation; T cell mediated immunity; cell surface receptor signaling pathway; cytotoxic T cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	925
	12525
	ENSG00000153563
	ENSMUSG00000053977
	P01732
	P01731
	NM_001145873; NM_001768; NM_171827
	NM_001081110; NM_009857
	NP_001139345; NP_001759; NP_741969; NP_001369627
	NP_001074579; NP_033987
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell surface glycoprotein CD8 alpha chain (Cluster of Differentiation 8a), is a protein encoded by CD8A gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153563 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053977 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD8A CD8a molecule".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153563 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053977 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD8A CD8a molecule".

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