CD90

THY1
Identifiers
Aliases	THY1, CD90, CDw90, Thy-1 cell surface antigen
External IDs	OMIM: 188230; MGI: 98747; HomoloGene: 4580; GeneCards: THY1; OMA:THY1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 119,415,476 bp[1] End 119,424,985 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.1|9 24.52 cM Start 43,954,681 bp[2] End 43,959,876 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex stromal cell of endometrium right frontal lobe gallbladder lateral nuclear group of thalamus Brodmann area 9 orbitofrontal cortex spinal ganglia nucleus accumbens superior frontal gyrus Top expressed in thymus primary visual cortex facial motor nucleus superior frontal gyrus dentate gyrus of hippocampal formation granule cell medial dorsal nucleus medial geniculate nucleus entorhinal cortex perirhinal cortex motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding enzyme binding GPI anchor binding GTPase activator activity protein kinase binding integrin binding Cellular component cytosol membrane focal adhesion growth cone anchored component of plasma membrane integral component of plasma membrane apical plasma membrane endoplasmic reticulum anchored component of membrane extracellular exosome external side of plasma membrane membrane raft anchored component of external side of plasma membrane dendrite myelin sheath extracellular region plasma membrane cell surface axolemma dendrite membrane neuronal cell body membrane Biological process negative regulation of T cell receptor signaling pathway positive regulation of GTPase activity protein autophosphorylation negative regulation of protein kinase activity cell adhesion negative regulation of cell migration angiogenesis negative regulation of axonogenesis cytoskeleton organization regulation of cell migration positive regulation of T cell activation T cell receptor signaling pathway retinal cone cell development positive regulation of release of sequestered calcium ion into cytosol C-terminal protein lipidation regulation of cell-matrix adhesion positive regulation of cellular extravasation integrin-mediated signaling pathway cell-cell signaling positive regulation of heterotypic cell-cell adhesion receptor clustering positive regulation of focal adhesion assembly negative regulation of protein tyrosine kinase activity negative regulation of neuron projection regeneration regulation of Rho-dependent protein serine/threonine kinase activity focal adhesion assembly cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7070 21838 Ensembl ENSG00000154096 ENSMUSG00000032011 UniProt P04216 P01831 RefSeq (mRNA) NM_006288 NM_001311160 NM_001311162 NM_001372050 NM_009382 RefSeq (protein) NP_001298089 NP_001298091 NP_006279 NP_001358979 NP_033408 Location (UCSC) Chr 11: 119.42 – 119.42 Mb Chr 9: 43.95 – 43.96 Mb PubMed search [3] [4]
Wikidata
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Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Structural study of Thy-1 led to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to some of the initial biochemical description and characterization of a vertebrate GPI anchor and also the first demonstration of tissue specific differential glycosylation.