CDC42

CDC42
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YDH, 1A4R, 1AJE, 1AM4, 1AN0, 1CEE, 1CF4, 1DOA, 1E0A, 1EES, 1GRN, 1GZS, 1KI1, 1KZ7, 1KZG, 1NF3, 2ASE, 2DFK, 2KB0, 2NGR, 2ODB, 2QRZ, 2WM9, 2WMN, 2WMO, 3GCG, 3QBV, 3VHL, 4DID, 4ITR, 4JS0, 4YC7, 5FI1
Identifiers
Aliases	CDC42, CDC42Hs, G25K, TKS, cell division cycle 42
External IDs	OMIM: 116952; MGI: 106211; HomoloGene: 123986; GeneCards: CDC42; OMA:CDC42 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 22,052,627 bp[1] End 22,101,360 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 69.83 cM Start 137,319,696 bp[2] End 137,357,720 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte islet of Langerhans rectum ganglionic eminence gallbladder epithelium of colon smooth muscle tissue olfactory zone of nasal mucosa granulocyte ventricular zone Top expressed in ascending aorta aortic valve Epithelium of choroid plexus endothelial cell of lymphatic vessel stroma of bone marrow medullary collecting duct renal corpuscle molar vestibular sensory epithelium dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Rho GDP-dissociation inhibitor binding ubiquitin protein ligase activity apolipoprotein A-I receptor binding GTP-dependent protein binding GTPase activity mitogen-activated protein kinase kinase kinase binding protein binding thioesterase binding protein kinase binding nucleotide binding GTP binding identical protein binding protein serine/threonine kinase activity GBD domain binding Cellular component cytoplasm cytosol membrane cell-cell junction focal adhesion microtubule organizing center spindle midzone neuron projection storage vacuole cytoskeleton cell projection myelin sheath extracellular exosome filopodium plasma membrane spindle apical part of cell secretory granule neuronal cell body cytoplasmic ribonucleoprotein granule mitotic spindle leading edge membrane cell periphery endoplasmic reticulum membrane Golgi membrane midbody centrosome cell cortex Golgi transport complex protein-containing complex dendritic spine Biological process cardiac conduction system development positive regulation of protein phosphorylation negative regulation of epidermal growth factor receptor signaling pathway positive regulation of muscle cell differentiation nuclear migration keratinization positive regulation of JNK cascade establishment of Golgi localization actin filament bundle assembly positive regulation of neuron apoptotic process vascular endothelial growth factor receptor signaling pathway hair follicle morphogenesis heart contraction regulation of protein stability neuron fate determination substantia nigra development Fc-gamma receptor signaling pathway involved in phagocytosis actin filament organization negative regulation of protein-containing complex assembly epithelial-mesenchymal cell signaling actin filament branching negative regulation of gene expression positive regulation of peptidyl-serine phosphorylation establishment or maintenance of cell polarity positive regulation of cell growth regulation of protein metabolic process establishment or maintenance of apical/basal cell polarity regulation of protein kinase activity regulation of attachment of spindle microtubules to kinetochore regulation of small GTPase mediated signal transduction positive regulation of hair follicle cell proliferation positive regulation of MAPK cascade regulation of mitotic nuclear division hair follicle placode formation positive regulation of intracellular protein transport cell differentiation positive regulation of epithelial cell proliferation involved in lung morphogenesis regulation of protein heterodimerization activity Golgi organization positive regulation of synapse structural plasticity multicellular organism growth epidermis morphogenesis nucleus localization epithelial cell-cell adhesion sprouting angiogenesis nervous system development macrophage differentiation dendritic cell migration positive regulation of cytokinesis positive regulation of DNA replication Wnt signaling pathway, planar cell polarity pathway keratinocyte development regulation of protein catabolic process canonical Wnt signaling pathway adherens junction organization organelle transport along microtubule actin cytoskeleton organization regulation of filopodium assembly endocytosis ephrin receptor signaling pathway filopodium assembly T cell costimulation blood coagulation positive regulation of phosphatidylinositol 3-kinase activity positive regulation of substrate adhesion-dependent cell spreading positive regulation of gene expression positive regulation of pseudopodium assembly submandibular salivary gland formation viral RNA genome replication small GTPase mediated signal transduction protein ubiquitination positive regulation of catalytic activity protein phosphorylation phagocytosis, engulfment integrin-mediated signaling pathway Rho protein signal transduction regulation of cell shape regulation of lamellipodium assembly positive regulation of lamellipodium assembly cell projection assembly Cdc42 protein signal transduction regulation of actin cytoskeleton organization cell junction assembly interleukin-12-mediated signaling pathway neuropilin signaling pathway establishment of epithelial cell apical/basal polarity positive regulation of filopodium assembly regulation of stress fiber assembly positive regulation of stress fiber assembly dendritic spine morphogenesis modification of synaptic structure positive regulation of actin cytoskeleton reorganization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 998 12540 Ensembl ENSG00000070831 ENSMUSG00000006699 UniProt P60953 P60766 RefSeq (mRNA) NM_044472 NM_001039802 NM_001791 NM_001243769 NM_009861 RefSeq (protein) NP_001034891 NP_001782 NP_426359 NP_001230698 NP_033991 Location (UCSC) Chr 1: 22.05 – 22.1 Mb Chr 4: 137.32 – 137.36 Mb PubMed search [3] [4]
Wikidata
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Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division,^[5][6] and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.