CDH16

CDH16
Identifiers
Aliases	CDH16, cadherin 16
External IDs	OMIM: 603118; MGI: 106671; HomoloGene: 2997; GeneCards: CDH16; OMA:CDH16 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,918,917 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,351,028 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; kidney tubule; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; muscle of thigh; ; caput epididymis; ; gonad;
	Top expressed in
	human kidney; ; right kidney; ; medullary collecting duct; ; proximal tubule; ; efferent ductule; ; vas deferens; ; renal corpuscle; ; left lung lobe; ; renal pelvis; ; trachea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding;
Cellular component	integral component of membrane; plasma membrane; extracellular exosome; membrane; integral component of plasma membrane; basolateral plasma membrane;
Biological process	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; cell-cell signaling; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	1014
	12556
	ENSG00000166589
	ENSMUSG00000031881
	O75309
	O88338
	NM_001204744; NM_001204745; NM_001204746; NM_004062
	NM_001252627; NM_001252628; NM_007663
	NP_001191673; NP_001191674; NP_001191675; NP_004053
	NP_001239556; NP_001239557; NP_031689
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.^[5]^[6]^[7]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166589 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031881 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics. 51 (3): 445–51. doi:10.1006/geno.1998.5402. PMID 9721215.
^ Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem. 270 (29): 17594–601. doi:10.1074/jbc.270.29.17594. PMID 7615566.
^ ^a ^b "Entrez Gene: CDH16 cadherin 16, KSP-cadherin".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166589 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031881 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9721215-5] Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics. 51 (3): 445–51. doi:10.1006/geno.1998.5402. PMID 9721215.

[pmid7615566-6] Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem. 270 (29): 17594–601. doi:10.1074/jbc.270.29.17594. PMID 7615566.

[entrez-7] "Entrez Gene: CDH16 cadherin 16, KSP-cadherin".

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