CDH3 (gene)

CDH3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OY9
Identifiers
Aliases	CDH3, CDHP, HJMD, PCAD, cadherin 3
External IDs	OMIM: 114021; MGI: 88356; HomoloGene: 20425; GeneCards: CDH3; OMA:CDH3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	68,727,468 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	107,283,929 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; lactiferous duct; ; gingival epithelium; ; olfactory zone of nasal mucosa; ; left ovary; ; retinal pigment epithelium; ; nasal epithelium; ; periodontal fiber; ; right ovary; ; hair follicle;
	Top expressed in
	decidua; ; gastrula; ; choroid plexus of fourth ventricle; ; genital tubercle; ; tail of embryo; ; lip; ; otic vesicle; ; saccule; ; secondary oocyte; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; molecular function; cytoskeletal protein binding; protein homodimerization activity; cadherin binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; cell surface; catenin complex;
Biological process	hair cycle process; positive regulation of keratinocyte proliferation; negative regulation of timing of catagen; response to stimulus; keratinization; wound healing; regulation of hair cycle by canonical Wnt signaling pathway; negative regulation of transforming growth factor beta2 production; positive regulation of tyrosinase activity; retina homeostasis; positive regulation of gene expression; cell adhesion; positive regulation of insulin-like growth factor receptor signaling pathway; canonical Wnt signaling pathway; positive regulation of melanin biosynthetic process; positive regulation of melanosome transport; adherens junction organization; visual perception; homophilic cell adhesion via plasma membrane adhesion molecules; cell-cell adhesion; positive regulation of canonical Wnt signaling pathway; cell-cell junction assembly; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1001
	12560
	ENSG00000062038
	ENSMUSG00000061048
	P22223
	P10287
	NM_001793; NM_001317195; NM_001317196
	NM_001037809; NM_007665
	NP_001304124; NP_001304125; NP_001784
	NP_001032898; NP_031691
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000062038 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061048 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
^ "Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000062038 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061048 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427864-5] Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.

[entrez-6] "Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)".

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