CDK5 regulatory subunit-associated protein 2 is a protein that in humans is encoded by the CDK5RAP2 gene. It has necessary roles in the formation and stability of microtubules from the centrosome[5] and has been found to be linked to human brain size variation in males.[6] Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined.[7][8]
CDK5RAP2 is homologous to the Drosophila protein centrosomin (cnn)[9] and paralogous to myomegalin, which in mammals contains an Olduvai domain, a domain implicated in human brain size evolution.[10][11]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000136861 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039298 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Fong KW, Choi YK, Rattner JB, Qi RZ (January 2008). "CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex". Molecular Biology of the Cell. 19 (1): 115–25. doi:10.1091/mbc.E07-04-0371. PMC 2174194. PMID 17959831.
- ^ Cite error: The named reference
pmid20080800was invoked but never defined (see the help page). - ^ Ching YP, Qi Z, Wang JH (January 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
- ^ "Entrez Gene: CDK5RAP2 CDK5 regulatory subunit associated protein 2".
- ^ Barr AR, Kilmartin JV, Gergely F (April 2010). "CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response". The Journal of Cell Biology. 189 (1): 23–39. doi:10.1083/jcb.200912163. PMC 2854379. PMID 20368616.
- ^ Dumas L, Kim YH, Karimpour-Fard A, Cox M, Hopkins J, Pollack JR, Sikela JM (September 2007). "Gene copy number variation spanning 60 million years of human and primate evolution". Genome Research. 17 (9): 1266–77. doi:10.1101/gr.6557307. PMC 1950895. PMID 17666543.
- ^ O'Bleness MS, Dickens CM, Dumas LJ, Kehrer-Sawatzki H, Wyckoff GJ, Sikela JM (September 2012). "Evolutionary history and genome organization of DUF1220 protein domains". G3. 2 (9): 977–86. doi:10.1534/g3.112.003061. PMC 3429928. PMID 22973535.