CDON

CDON
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D1M, 3N1F, 3N1Q
Identifiers
Aliases	CDON, CDO, CDON1, HPE11, ORCAM, cell adhesion associated, oncogene regulated, Ihog
External IDs	OMIM: 608707; MGI: 1926387; HomoloGene: 22996; GeneCards: CDON; OMA:CDON - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	126,063,335 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	35,507,652 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; germinal epithelium; ; synovial joint; ; parietal pleura; ; left uterine tube; ; skin of hip; ; right ovary; ; left ovary;
	Top expressed in
	vestibular membrane of cochlear duct; ; ventricular zone; ; vestibular sensory epithelium; ; ciliary body; ; vas deferens; ; utricle; ; efferent ductule; ; iris; ; foot; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; membrane; extracellular matrix; plasma membrane; integral component of plasma membrane; collagen-containing extracellular matrix;
Biological process	regulation of neuron differentiation; positive regulation of small GTPase mediated signal transduction; positive regulation of protein phosphorylation; regulation of protein heterodimerization activity; positive regulation of skeletal muscle tissue development; positive regulation of muscle cell differentiation; embryonic body morphogenesis; cell fate specification; skeletal muscle satellite cell differentiation; positive regulation of neural precursor cell proliferation; lens development in camera-type eye; positive regulation of myoblast differentiation; embryonic morphogenesis; positive regulation of neuron differentiation; cerebral cortex development; embryonic retina morphogenesis in camera-type eye; smoothened signaling pathway; striated muscle cell differentiation; myoblast fusion; anterior/posterior pattern specification; positive regulation of MAPK cascade; positive regulation of transcription by RNA polymerase II; cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	50937
	57810
	ENSG00000064309
	ENSMUSG00000038119
	Q4KMG0
	Q32MD9
	NM_001243597; NM_016952; NM_001378964
	NM_021339
	NP_001230526; NP_058648; NP_001365893
NP_067314; NP_001392175; NP_001392176; NP_001392177; NP_001392178;
	NP_001392179; NP_001392180
	Wikidata
View/Edit Human	View/Edit Mouse

Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.^[5]^[6]

CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064309 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038119 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kang JS, Gao M, Feinleib JL, Cotter PD, Guadagno SN, Krauss RS (July 1997). "CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family". The Journal of Cell Biology. 138 (1): 203–13. doi:10.1083/jcb.138.1.203. PMC 2139939. PMID 9214393.
^ ^a ^b "Entrez Gene: CDON Cdon homolog (mouse)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064309 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038119 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9214393-5] Kang JS, Gao M, Feinleib JL, Cotter PD, Guadagno SN, Krauss RS (July 1997). "CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family". The Journal of Cell Biology. 138 (1): 203–13. doi:10.1083/jcb.138.1.203. PMC 2139939. PMID 9214393.

[entrez-6] "Entrez Gene: CDON Cdon homolog (mouse)".

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