CEBPA

CEBPA
Identifiers
Aliases	CEBPA, C/EBP-alpha, CEBP, CCAAT/enhancer binding protein alpha, CCAAT enhancer binding protein alpha
External IDs	OMIM: 116897; MGI: 99480; HomoloGene: 3211; GeneCards: CEBPA; OMA:CEBPA - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.11 Start 33,299,934 bp[1] End 33,302,534 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B2|7 21.02 cM Start 34,818,718 bp[2] End 34,821,353 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple skin of arm human penis skin of thigh skin of abdomen right lobe of liver monocyte adipose tissue subcutaneous adipose tissue vulva Top expressed in lactiferous gland brown adipose tissue subcutaneous adipose tissue white adipose tissue lip tunica adventitia of aorta skin of external ear stroma of bone marrow right lung gallbladder More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding protein homodimerization activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription coactivator activity transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding kinase binding protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex RNA polymerase II transcription regulator complex nucleolus nucleus nucleoplasm intracellular membrane-bounded organelle Biological process Notch signaling pathway transcription by RNA polymerase I myeloid cell differentiation regulation of transcription, DNA-templated cellular response to lithium ion glucose homeostasis negative regulation of cyclin-dependent protein serine/threonine kinase activity lung development cytokine-mediated signaling pathway urea cycle regulation of transcription by RNA polymerase II cellular response to organic cyclic compound mitochondrion organization embryonic placenta development cholesterol metabolic process negative regulation of cell cycle negative regulation of transcription by RNA polymerase II cell maturation generation of precursor metabolites and energy transcription, DNA-templated macrophage differentiation multicellular organism development positive regulation of transcription, DNA-templated positive regulation of osteoblast differentiation granulocyte differentiation regulation of cell population proliferation brown fat cell differentiation lipid homeostasis white fat cell differentiation inner ear development liver development viral process negative regulation of transcription, DNA-templated positive regulation of fat cell differentiation positive regulation of transcription by RNA polymerase III fat cell differentiation positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation transcription by RNA polymerase II cellular response to tumor necrosis factor positive regulation of DNA-templated transcription, initiation positive regulation of macrophage activation positive regulation of inflammatory response interleukin-6-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1050 12606 Ensembl ENSG00000245848 ENSMUSG00000034957 UniProt P49715 P53566 RefSeq (mRNA) NM_004364 NM_001285829 NM_001287424 NM_001287435 NM_001287514 NM_001287515 NM_001287521 NM_001287523 NM_007678 RefSeq (protein) NP_001272758 NP_001274353 NP_001274364 NP_004355 NP_001274443 NP_001274444 NP_001274450 NP_001274452 NP_031704 Location (UCSC) Chr 19: 33.3 – 33.3 Mb Chr 7: 34.82 – 34.82 Mb PubMed search [3] [4]
Wikidata
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CCAAT/enhancer-binding protein alpha is a protein encoded by the CEBPA gene in humans.^[5][6] CCAAT/enhancer-binding protein alpha is a transcription factor involved in the differentiation of certain blood cells.^[7] For details on the CCAAT structural motif in gene enhancers and on CCAAT/Enhancer Binding Proteins see the specific page.