CEBPB

CEBPB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GTW, 1GU4, 1GU5, 1H88, 1H89, 1H8A, 1HJB, 1IO4, 2E42, 2E43
Identifiers
Aliases	CEBPB, C/EBP-beta, IL6DBP, NF-IL6, TCF5, CCAAT/enhancer binding protein beta, CCAAT enhancer binding protein beta
External IDs	OMIM: 189965; MGI: 88373; HomoloGene: 3807; GeneCards: CEBPB; OMA:CEBPB - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	50,192,668 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	167,532,338 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; pericardium; ; periodontal fiber; ; vena cava; ; mucosa of paranasal sinus; ; nipple; ; lactiferous duct; ; skin of thigh; ; tibialis anterior muscle; ; skin of arm;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; hair follicle; ; left lung lobe; ; brown adipose tissue; ; decidua; ; gastrula; ; temporal muscle; ; right lung lobe; ; left lobe of liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; histone deacetylase binding; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; kinase binding; protein binding; histone acetyltransferase binding; ubiquitin-like protein ligase binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; glucocorticoid receptor binding;
Cellular component	cytoplasm; nuclear matrix; CHOP-C/EBP complex; nucleoplasm; nucleus; condensed chromosome, centromeric region; RNA polymerase II transcription regulator complex;
Biological process	negative regulation of neuron apoptotic process; mammary gland epithelial cell proliferation; cell differentiation; regulation of transcription, DNA-templated; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; cellular response to organic cyclic compound; embryonic placenta development; memory; positive regulation of interleukin-4 production; response to endoplasmic reticulum stress; mammary gland epithelial cell differentiation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; negative regulation of T cell proliferation; liver regeneration; positive regulation of osteoblast differentiation; hepatocyte proliferation; response to lipopolysaccharide; regulation of osteoclast differentiation; defense response to bacterium; acute-phase response; immune response; neuron differentiation; cellular response to interleukin-1; brown fat cell differentiation; cellular response to amino acid stimulus; ovarian follicle development; liver development; inflammatory response; negative regulation of transcription, DNA-templated; positive regulation of fat cell differentiation; cellular response to lipopolysaccharide; fat cell differentiation; positive regulation of transcription by RNA polymerase II; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; transcription by RNA polymerase II; granuloma formation; T-helper 1 cell activation; negative regulation of transcription by RNA polymerase II; regulation of odontoblast differentiation; positive regulation of biomineral tissue development; positive regulation of sodium-dependent phosphate transport; positive regulation of inflammatory response; positive regulation of cold-induced thermogenesis; regulation of dendritic cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1051
	12608
	ENSG00000172216
	ENSMUSG00000056501
	P17676
	P28033
	NM_005194; NM_001285878; NM_001285879
	NM_001287738; NM_001287739; NM_009883
	NP_001272807; NP_001272808; NP_005185
	NP_001274667; NP_001274668; NP_034013
	Wikidata
View/Edit Human	View/Edit Mouse

CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172216 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056501 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (June 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.
^ Cao Z, Umek RM, McKnight SL (September 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–1552. doi:10.1101/gad.5.9.1538. PMID 1840554.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172216 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056501 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1535333-5] Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (June 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.

[pmid1840554-6] Cao Z, Umek RM, McKnight SL (September 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–1552. doi:10.1101/gad.5.9.1538. PMID 1840554.

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