CELA1

CELA1
Identifiers
Aliases	CELA1, ELA1, chymotrypsin like elastase family member 1, chymotrypsin like elastase 1
External IDs	OMIM: 130120; MGI: 95314; HomoloGene: 20454; GeneCards: CELA1; OMA:CELA1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	51,346,679 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	100,585,802 bp
RNA expression pattern
	Top expressed in
	testicle; ; left adrenal gland; ; right adrenal cortex; ; granulocyte; ; left adrenal cortex; ; monocyte; ; gonad; ; stromal cell of endometrium; ; blood; ; lymph node;
	Top expressed in
	pyloric antrum; ; islet of Langerhans; ; left colon; ; right kidney; ; transitional epithelium of urinary bladder; ; duodenum; ; human kidney; ; lens; ; epithelium of stomach; ; epithelium of lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	extracellular region; extracellular space;
Biological process	exocrine pancreas development; digestive system development; pancreas morphogenesis; multicellular organism growth; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; post-embryonic development; proteolysis; positive regulation of angiogenesis; regulation of cell population proliferation; regulation of cell differentiation; elastin catabolic process; inflammatory response; tissue remodeling; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1990
	109901
	ENSG00000139610
	ENSMUSG00000023031
	Q9UNI1
	Q91X79
	NM_001971
	NM_033612
	NP_001962
	NP_291090
	Wikidata
View/Edit Human	View/Edit Mouse

Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an enzyme that in humans is encoded by the CELA1 gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139610 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023031 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139610 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023031 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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