CELA3B

CELA3B
Identifiers
Aliases	CELA3B, CBPP, E1, EL-1, ELA3B, chymotrypsin like elastase family member 3B, chymotrypsin like elastase 3B
External IDs	MGI: 1915118; HomoloGene: 128227; GeneCards: CELA3B; OMA:CELA3B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	21,998,642 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,157,851 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; testicle; ; body of stomach; ; fundus; ; duodenum; ; ectocervix; ; right coronary artery; ; right lobe of liver; ; placenta;
	Top expressed in
	pyloric antrum; ; islet of Langerhans; ; duodenum; ; sexually immature organism; ; morula; ; embryo; ; esophagus; ; brown adipose tissue; ; gastric mucosa; ; mucous cell of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity;
Cellular component	extracellular space;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	23436
	67868
	ENSG00000219073
	ENSMUSG00000023433
	P08861
	Q9CQ52
	NM_007352
	NM_026419
	NP_031378
	NP_080695
	Wikidata
View/Edit Human	View/Edit Mouse

Chymotrypsin-like elastase family member 3B also known as elastase-3B, protease E, or fecal elastase is an enzyme that in humans is encoded by the CELA3B gene.^[5]^[6]^[7]

Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family member 3B (i.e. the enzyme / protein this article focuses on).^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000219073 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023433 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tani T, Ohsumi J, Mita K, Takiguchi Y (Feb 1988). "Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning". J Biol Chem. 263 (3): 1231–9. doi:10.1016/S0021-9258(19)57291-X. PMID 2826474.
^ Shirasu Y, Takemura K, Yoshida H, Sato Y, Iijima H, Shimada Y, Mikayama T, Ozawa T, Ikeda N, Ishida A, et al. (Dec 1988). "Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes". J Biochem. 104 (2): 259–64. doi:10.1093/oxfordjournals.jbchem.a122454. PMID 2460440.
^ "Entrez Gene: ELA3B elastase 3B, pancreatic".
^ "Entrez Gene: chymotrypsin-like elastase family, member 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000219073 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023433 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2826474-5] Tani T, Ohsumi J, Mita K, Takiguchi Y (Feb 1988). "Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning". J Biol Chem. 263 (3): 1231–9. doi:10.1016/S0021-9258(19)57291-X. PMID 2826474.

[pmid2460440-6] Shirasu Y, Takemura K, Yoshida H, Sato Y, Iijima H, Shimada Y, Mikayama T, Ozawa T, Ikeda N, Ishida A, et al. (Dec 1988). "Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes". J Biochem. 104 (2): 259–64. doi:10.1093/oxfordjournals.jbchem.a122454. PMID 2460440.

[entrez-7] "Entrez Gene: ELA3B elastase 3B, pancreatic".

[entrez2-8] "Entrez Gene: chymotrypsin-like elastase family, member 1".

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