CELSR1

CELSR1
Identifiers
Aliases	CELSR1, CDHF9, FMI2, HFMI2, ME2, ADGRC1, cadherin EGF LAG seven-pass G-type receptor 1, LMPHM9
External IDs	OMIM: 604523; MGI: 1100883; HomoloGene: 7665; GeneCards: CELSR1; OMA:CELSR1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	46,537,620 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	85,918,404 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; bronchial epithelial cell; ; right uterine tube; ; olfactory zone of nasal mucosa; ; ganglionic eminence; ; skin of abdomen; ; anterior pituitary; ; skin of leg; ; secondary oocyte; ; mucosa of paranasal sinus;
	Top expressed in
	ventricular zone; ; molar; ; vestibular sensory epithelium; ; hair follicle; ; lip; ; medullary collecting duct; ; skin of external ear; ; tail of embryo; ; secondary oocyte; ; primary oocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; protein dimerization activity; signal transducer activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; nucleoplasm;
Biological process	hair follicle development; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; G protein-coupled receptor signaling pathway; lateral sprouting involved in lung morphogenesis; regulation of actin cytoskeleton organization; locomotory behavior; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; establishment of planar polarity of embryonic epithelium; establishment of planar polarity; wound healing; neuron migration; establishment of body hair planar orientation; planar cell polarity pathway involved in neural tube closure; multicellular organism development; Wnt signaling pathway, planar cell polarity pathway; central nervous system development; cell surface receptor signaling pathway; neural tube closure; cell adhesion; inner ear morphogenesis; apical protein localization; Rho protein signal transduction; anterior/posterior pattern specification; signal transduction; homophilic cell adhesion via plasma membrane adhesion molecules; protein localization involved in establishment of planar polarity; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	9620
	12614
	ENSG00000075275
	ENSMUSG00000016028
	Q9NYQ6
	O35161
	NM_014246; NM_001378328
	NM_009886
	NP_055061; NP_001365257
	NP_034016
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075275 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016028 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF (Nov 1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter" (PDF). Genomics. 45 (1): 97–104. doi:10.1006/geno.1997.4892. PMID 9339365. Archived (PDF) from the original on 2019-02-18. Retrieved 2019-09-17.
^ "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)". Archived from the original on 2024-05-02. Retrieved 2017-08-30.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075275 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016028 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9339365-5] Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF (Nov 1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter" (PDF). Genomics. 45 (1): 97–104. doi:10.1006/geno.1997.4892. PMID 9339365. Archived (PDF) from the original on 2019-02-18. Retrieved 2019-09-17.

[entrez-6] "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)". Archived from the original on 2024-05-02. Retrieved 2017-08-30.

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