CENPF

CENPF
Identifiers
Aliases	CENPF, CENF, PRO1779, hcp-1, CILD31, STROMS, centromere protein F
External IDs	OMIM: 600236; MGI: 1313302; HomoloGene: 22969; GeneCards: CENPF; OMA:CENPF - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	214,664,571 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	189,420,283 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; testicle; ; trabecular bone; ; stromal cell of endometrium; ; bone marrow; ; bone marrow cells; ; mucosa of transverse colon; ; left testis;
	Top expressed in
	zygote; ; primary oocyte; ; tail of embryo; ; genital tubercle; ; maxillary prominence; ; ventricular zone; ; secondary oocyte; ; fetal liver hematopoietic progenitor cell; ; superior cervical ganglion; ; mandibular prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; transcription factor binding; chromatin binding; protein C-terminus binding; protein binding; dynein complex binding;
Cellular component	cytoplasm; ciliary basal body; cytosol; centrosome; spindle pole; nuclear envelope; nuclear matrix; spindle; nucleoplasm; ciliary transition fiber; chromosome; midbody; outer kinetochore; perinuclear region of cytoplasm; pronucleus; axoneme; chromatin; chromosome, centromeric region; cytoskeleton; nucleus; kinetochore;
Biological process	regulation of G2/M transition of mitotic cell cycle; regulation of striated muscle tissue development; cell differentiation; metaphase plate congression; DNA biosynthetic process; kidney development; chromosome segregation; muscle organ development; ventricular system development; mitotic spindle assembly checkpoint signaling; regulation of cell cycle; cell division; multicellular organism development; protein transport; cell cycle; cell population proliferation; negative regulation of transcription, DNA-templated; kinetochore assembly; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1063
	108000
	ENSG00000117724
	ENSMUSG00000026605
	P49454
	n/a
	NM_016343
	NM_001081363
	NP_057427
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein F is a protein that in humans is encoded by the CENPF gene.^[5]^[6]^[7] It is involved in chromosome segregation during cell division. It also has a role in the orientation of microtubules to form cellular cilia.^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117724 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026605 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rattner JB, Rao A, Fritzler MJ, Valencia DW, Yen TJ (Mar 1994). "CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization". Cell Motil Cytoskeleton. 26 (3): 214–26. doi:10.1002/cm.970260305. PMID 7904902.
^ Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics. 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898.
^ "Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)".
^ Waters, Aoife M.; Asfahani, Rowan; Carroll, Paula; Bicknell, Louise; Lescai, Francesco; Bright, Alison; Chanudet, Estelle; Brooks, Anthony; Christou-Savina, Sonja; Osman, Guled; Walsh, Patrick (March 2015). "The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes". Journal of Medical Genetics. 52 (3): 147–156. doi:10.1136/jmedgenet-2014-102691. ISSN 1468-6244. PMC 4345935. PMID 25564561.
^ Filges, Isabel; Bruder, Elisabeth; Brandal, Kristin; Meier, Stephanie; Undlien, Dag Erik; Waage, Trine Rygvold; Hoesli, Irene; Schubach, Max; de Beer, Tjaart; Sheng, Ying; Hoeller, Sylvia (April 2016). "Strømme Syndrome Is a Ciliary Disorder Caused by Mutations in CENPF". Human Mutation. 37 (4): 359–363. doi:10.1002/humu.22960. ISSN 1098-1004. PMID 26820108. S2CID 1495539.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117724 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026605 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7904902-5] Rattner JB, Rao A, Fritzler MJ, Valencia DW, Yen TJ (Mar 1994). "CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization". Cell Motil Cytoskeleton. 26 (3): 214–26. doi:10.1002/cm.970260305. PMID 7904902.

[pmid7851898-6] Testa JR, Zhou JY, Bell DW, Yen TJ (Mar 1995). "Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→q25 and 1q32→q41, respectively, by fluorescence in situ hybridization". Genomics. 23 (3): 691–3. doi:10.1006/geno.1994.1558. PMID 7851898.

[entrez-7] "Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)".

[:5-8] Waters, Aoife M.; Asfahani, Rowan; Carroll, Paula; Bicknell, Louise; Lescai, Francesco; Bright, Alison; Chanudet, Estelle; Brooks, Anthony; Christou-Savina, Sonja; Osman, Guled; Walsh, Patrick (March 2015). "The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes". Journal of Medical Genetics. 52 (3): 147–156. doi:10.1136/jmedgenet-2014-102691. ISSN 1468-6244. PMC 4345935. PMID 25564561.

[:72-9] Filges, Isabel; Bruder, Elisabeth; Brandal, Kristin; Meier, Stephanie; Undlien, Dag Erik; Waage, Trine Rygvold; Hoesli, Irene; Schubach, Max; de Beer, Tjaart; Sheng, Ying; Hoeller, Sylvia (April 2016). "Strømme Syndrome Is a Ciliary Disorder Caused by Mutations in CENPF". Human Mutation. 37 (4): 359–363. doi:10.1002/humu.22960. ISSN 1098-1004. PMID 26820108. S2CID 1495539.

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