CHEK2

CHEK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U, 3I6W, 4A9R, 4A9S, 4A9T, 4A9U, 4BDA, 4BDB, 4BDC, 4BDD, 4BDE, 4BDF, 4BDG, 4BDH, 4BDI, 4BDJ, 4BDK, 2WTI, 2WTJ, 2XK9
Identifiers
Aliases	CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2
External IDs	OMIM: 604373; MGI: 1355321; HomoloGene: 38289; GeneCards: CHEK2; OMA:CHEK2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.1 Start 28,687,743 bp[1] End 28,742,422 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 110,987,845 bp[2] End 111,022,011 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle mucosa of transverse colon tibial nerve oocyte secondary oocyte rectum ventricular zone left ovary right ovary Top expressed in morula morula fetal liver hematopoietic progenitor cell epiblast Ileal epithelium blastocyst embryo Paneth cell primitive streak thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity metal ion binding protein serine/threonine kinase activity protein binding identical protein binding protein kinase binding ATP binding ubiquitin protein ligase binding kinase activity Cellular component PML body Golgi apparatus nucleoplasm telomere nucleus cytoplasm Biological process positive regulation of protein phosphorylation regulation of transcription, DNA-templated cellular response to bisphenol A negative regulation of DNA damage checkpoint phosphorylation signal transduction in response to DNA damage replicative senescence DNA damage checkpoint signaling protein stabilization transcription, DNA-templated cellular response to DNA damage stimulus cell division positive regulation of transcription, DNA-templated protein phosphorylation mitotic spindle assembly G2/M transition of mitotic cell cycle intrinsic apoptotic signaling pathway in response to DNA damage DNA damage induced protein phosphorylation regulation of protein catabolic process protein autophosphorylation cell cycle positive regulation of anoikis response to gamma radiation apoptotic process double-strand break repair DNA repair DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of signal transduction by p53 class mediator DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process cellular response to gamma radiation response to glycoside mitotic DNA damage checkpoint signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11200 50883 Ensembl ENSG00000183765 ENSMUSG00000029521 UniProt O96017 Q9Z265 RefSeq (mRNA) NM_001005735 NM_001257387 NM_007194 NM_145862 NM_001349956 NM_016681 NM_001363308 RefSeq (protein) NP_001005735 NP_001244316 NP_009125 NP_665861 NP_001336885 NP_057890 NP_001350237 Location (UCSC) Chr 22: 28.69 – 28.74 Mb Chr 5: 110.99 – 111.02 Mb PubMed search [3] [4]
Wikidata
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CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.^[5]