CHRNB1

CHRNB1
Identifiers
Aliases	CHRNB1, ACHRB, CHRNB, CMS1D, CMS2A, SCCMS, CMS2C, cholinergic receptor nicotinic beta 1 subunit
External IDs	OMIM: 100710; MGI: 87890; HomoloGene: 594; GeneCards: CHRNB1; OMA:CHRNB1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,457,710 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,686,769 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; skeletal muscle tissue; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; placenta; ; right lobe of liver; ; amygdala; ; granulocyte;
	Top expressed in
	muscle of thigh; ; extraocular muscle; ; ankle; ; ankle joint; ; vastus lateralis muscle; ; temporal muscle; ; thoracic diaphragm; ; tongue muscle; ; medial head of gastrocnemius muscle; ; tibialis anterior muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	channel activity; acetylcholine binding; acetylcholine receptor activity; ion channel activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; acetylcholine-gated channel complex; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; neuromuscular junction; integral component of postsynaptic specialization membrane; neuron projection;
Biological process	muscle contraction; regulation of membrane potential; skeletal muscle contraction; cation transport; nervous system process; synaptic transmission, cholinergic; ion transport; behavioral response to nicotine; neuromuscular synaptic transmission; postsynaptic membrane organization; signal transduction; cation transmembrane transport; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; ion transmembrane transport; chemical synaptic transmission; response to nicotine;
	Sources:Amigo / QuickGO
Orthologs
	1140
	11443
	ENSG00000170175; ENSG00000283946
	ENSMUSG00000041189
	P11230
	P09690
	NM_000747
	NM_009601
	NP_000738
	NP_033731
	Wikidata
View/Edit Human	View/Edit Mouse

Acetylcholine receptor subunit beta is a protein that in humans is encoded by the CHRNB1 gene.^[5]

The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.^[5]

^ ^a ^b ^c ENSG00000283946 GRCh38: Ensembl release 89: ENSG00000170175, ENSG00000283946 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041189 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)".

[refGRCh38Ensembl-1] ENSG00000283946 GRCh38: Ensembl release 89: ENSG00000170175, ENSG00000283946 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041189 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)".

[1]

[2]

[3]

[4]

[5]