CHRNG

CHRNG
Identifiers
Aliases	CHRNG, ACHRG, cholinergic receptor nicotinic gamma subunit
External IDs	OMIM: 100730; MGI: 87895; HomoloGene: 3810; GeneCards: CHRNG; OMA:CHRNG - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	232,548,115 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,140,416 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; cerebellar vermis; ; glutes; ; synovial joint; ; human penis; ; periodontal fiber; ; skeletal muscle tissue; ; sural nerve; ; seminal vesicula;
	Top expressed in
	lens; ; internal carotid artery; ; mylohyoid muscle; ; tongue muscle; ; erector spinae muscles; ; tongue; ; Psoas; ; zygote; ; shoulder; ; psoas major muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	channel activity; acetylcholine binding; acetylcholine receptor activity; ion channel activity; protein binding; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; acetylcholine-gated channel complex; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; neuron projection;
Biological process	muscle contraction; response to nicotine; synaptic transmission, cholinergic; ion transport; cation transmembrane transport; neuromuscular synaptic transmission; signal transduction; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; ion transmembrane transport; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	1146
	11449
	ENSG00000196811
	ENSMUSG00000026253
	P07510
	P04760
	NM_005199
	NM_009604
	NP_005190
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Acetylcholine receptor subunit gamma is a protein that in humans is encoded by the CHRNG gene.^[5]

For background information on the acetylcholine receptor (AChR), see CHRNA1 (MIM 100690). Two forms of AChR are found in mammalian skeletal muscle cells. The mature form is predominant in innervated adult muscle and the embryonic form is present in fetal and denervated muscle. Embryonic and mature AChR differ by the replacement of the gamma subunit in the pentameric glycoprotein complex by its isoform, the epsilon subunit (MIM 100725), which is specific to the mature AChR subtype. This switch is mediated by ARIA (acetylcholine receptor-inducing activity; MIM 142445).[supplied by OMIM]^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196811 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026253 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CHRNG cholinergic receptor, nicotinic, gamma".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196811 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026253 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CHRNG cholinergic receptor, nicotinic, gamma".

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