CKB (gene)

creatine kinase, ectopic expression
creatine kinase, ectopic expression
Identifiers
Symbol	CKBE
NCBI gene	1156
HGNC	1992
OMIM	123270
Other data
Locus	Chr. 14 q32.3

CKB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B6R, 3DRB, 3DRE
Identifiers
Aliases	CKB, B-CK, BCK, CKBB, HEL-211, HEL-S-29, creatine kinase B, CPK-B
External IDs	OMIM: 123280; MGI: 88407; HomoloGene: 37530; GeneCards: CKB; OMA:CKB - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	103,522,833 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,638,772 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; ventricular zone; ; right frontal lobe; ; prefrontal cortex; ; caudate nucleus; ; nucleus accumbens; ; muscle layer of sigmoid colon; ; amygdala; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	cerebellar cortex; ; olfactory bulb; ; Cortex of frontal lobe; ; superior frontal gyrus; ; striatum of neuraxis; ; primary visual cortex; ; neural tube; ; mesencephalon; ; hypothalamus; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; transferase activity, transferring phosphorus-containing groups; kinase activity; creatine kinase activity; catalytic activity; protein binding; ATP binding; ubiquitin protein ligase binding;
Cellular component	myelin sheath; mitochondrion; extracellular exosome; extracellular space; nucleus; cytoplasm; cytosol; dendrite; neuronal cell body;
Biological process	substantia nigra development; phosphorylation; brain development; creatine metabolic process; cellular chloride ion homeostasis; cerebellum development; phosphocreatine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1152
	12709
	ENSG00000166165
	ENSMUSG00000001270
	P12277
	Q04447
	NM_001823; NM_001362531
	NM_021273
	NP_001814; NP_001349460
	NP_067248
	Wikidata
View/Edit Human	View/Edit Mouse

Brain-type creatine kinase also known as CK-BB is a creatine kinase that in humans is encoded by the CKB gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166165 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001270 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mariman EC, Schepens JT, Wieringa B (August 1989). "Complete nucleotide sequence of the human creatine kinase B gene". Nucleic Acids Res. 17 (15): 6385. doi:10.1093/nar/17.15.6385. PMC 318286. PMID 2771648.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166165 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001270 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2771648-5] Mariman EC, Schepens JT, Wieringa B (August 1989). "Complete nucleotide sequence of the human creatine kinase B gene". Nucleic Acids Res. 17 (15): 6385. doi:10.1093/nar/17.15.6385. PMC 318286. PMID 2771648.

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