CKLF (gene)

CKLF
Identifiers
Aliases	CKLF, C32, CKLF1, CKLF2, CKLF3, CKLF4, UCK-1, HSPC224, chemokine-like factor, chemokine like factor
External IDs	OMIM: 616074; MGI: 1922708; HomoloGene: 9663; GeneCards: CKLF; OMA:CKLF - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,566,251 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	104,991,570 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; appendix; ; lymph node; ; spleen; ; left testis; ; right testis; ; islet of Langerhans; ; rectum;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; granulocyte; ; adrenal gland; ; medullary collecting duct; ; spleen; ; tail of embryo; ; renal corpuscle; ; endothelial cell of lymphatic vessel;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chemokine activity; cytokine activity;
Cellular component	integral component of membrane; extracellular region; membrane; extracellular space;
Biological process	lymphocyte chemotaxis; chemotaxis; macrophage chemotaxis; cell population proliferation; secretion by cell; neutrophil chemotaxis; leukocyte chemotaxis; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	51192
	75458
	ENSG00000217555
	ENSMUSG00000054400
	Q9UBR5
	Q9DAS1
NM_181641; NM_001040138; NM_001040139; NM_016326; NM_016951;
	NM_181640
	NM_001037840; NM_001037841; NM_001286383; NM_029295; NM_029313
	NP_001035228; NP_057410; NP_058647; NP_857591; NP_857592
	NP_001032930; NP_001273312; NP_083571
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine-like factor (CKLF) is a member of the CKLF-like MARVEL transmembrane domain-containing family of proteins that in humans is encoded by the CKLF gene.^[5]^[6] This gene is located on band 22.1 in the long (i.e. "q") arm of chromosome 16.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000217555 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054400 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–1560. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
^ Han W, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, et al. (July 2001). "Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity". The Biochemical Journal. 357 (Pt 1): 127–135. doi:10.1042/0264-6021:3570127. PMC 1221935. PMID 11415443.
^ Duan HJ, Li XY, Liu C, Deng XL (April 2020). "Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases". Chinese Medical Journal. 133 (8): 951–958. doi:10.1097/CM9.0000000000000747. PMC 7176445. PMID 32195671.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000217555 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054400 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11042152-5] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–1560. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

[pmid11415443-6] Han W, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, et al. (July 2001). "Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity". The Biochemical Journal. 357 (Pt 1): 127–135. doi:10.1042/0264-6021:3570127. PMC 1221935. PMID 11415443.

[pmid32195671-7] Duan HJ, Li XY, Liu C, Deng XL (April 2020). "Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases". Chinese Medical Journal. 133 (8): 951–958. doi:10.1097/CM9.0000000000000747. PMC 7176445. PMID 32195671.

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