CKMT1A

creatine kinase, mitochondrial 1A
Identifiers
SymbolCKMT1A
Alt. symbolsCKMT1
NCBI gene548596
HGNC31736
RefSeqNM_001015001
UniProtP12532
Other data
EC number2.7.3.2
LocusChr. 15 q15
Search for
StructuresSwiss-model
DomainsInterPro

Creatine kinase U-type, mitochondrial, also called ubiquitous mitochondrial creatine kinase (uMtCK), is in humans encoded by CKMT1A gene. CKMT1A catalyzes the reversible transfer of the γ-phosphate group of ATP to the guanidino group of Cr to yield ADP and PCr. The impairment of CKMT1A has been reported in ischaemia, cardiomyopathy, and neurodegenerative disorders. Overexpression of CKMT1A has been reported related with several tumors.[1][2][3]

  1. ^ Haas RC, Korenfeld C, Zhang ZF, Perryman B, Roman D, Strauss AW (February 1989). "Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase". The Journal of Biological Chemistry. 264 (5): 2890–7. doi:10.1016/S0021-9258(19)81696-4. PMID 2914937.
  2. ^ Stachowiak O, Schlattner U, Dolder M, Wallimann T (July 1998). "Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: implications for cellular function and mitochondrial structure". Molecular and Cellular Biochemistry. 184 (1–2): 141–51. doi:10.1023/A:1006803431821. PMID 9746318. S2CID 22668868.
  3. ^ Lipskaya TY (October 2001). "Mitochondrial creatine kinase: properties and function". Biochemistry. Biokhimiia. 66 (10): 1098–111. doi:10.1023/A:1012428812780. PMID 11736631. S2CID 32593074.