CLCA4

CLCA4
Identifiers
Aliases	CLCA4, CaCC, CaCC2, chloride channel accessory 4
External IDs	OMIM: 616857; MGI: 2139744; HomoloGene: 40808; GeneCards: CLCA4; OMA:CLCA4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	86,580,754 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	144,680,806 bp
RNA expression pattern
	Top expressed in
	mucosa of colon; ; mucosa of sigmoid colon; ; oral cavity; ; mucosa of pharynx; ; rectum; ; mucosa of transverse colon; ; cervix epithelium; ; mucosa of urinary bladder; ; mucosa of ileum; ; nasal epithelium;
	Top expressed in
	jejunum; ; Paneth cell; ; left colon; ; ileum; ; duodenum; ; conjunctival fornix; ; lumbar subsegment of spinal cord; ; cornea; ; ciliary body; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; chloride channel activity; metalloendopeptidase activity; intracellular calcium activated chloride channel activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; apical plasma membrane; membrane;
Biological process	ion transmembrane transport; chloride transport; proteolysis; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	22802
	99663
	ENSG00000016602
	ENSMUSG00000068547
	Q14CN2
	Q6Q473
	NM_012128
	NM_207208
	NP_036260
	NP_997091
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.^[5] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000016602 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068547 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792. S2CID 82094058.
^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000016602 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068547 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10437792-5] Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792. S2CID 82094058.

[pmid16470849-6] Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

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