CLCC1

CLCC1
Identifiers
Aliases	CLCC1, MCLC, chloride channel CLIC like 1
External IDs	OMIM: 617539; MGI: 2385186; HomoloGene: 9032; GeneCards: CLCC1; OMA:CLCC1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	108,963,457 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	108,586,156 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; buccal mucosa cell; ; Achilles tendon; ; internal globus pallidus; ; stromal cell of endometrium; ; body of pancreas; ; islet of Langerhans; ; gastrocnemius muscle; ; epithelium of colon; ; corpus callosum;
	Top expressed in
	spermatocyte; ; seminal vesicula; ; intercostal muscle; ; primary oocyte; ; right kidney; ; parotid gland; ; lobe of cerebellum; ; median eminence; ; Gonadal ridge; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	chloride channel activity;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum; membrane; nucleus; chloride channel complex; intracellular membrane-bounded organelle;
Biological process	chloride transport; chloride transmembrane transport; ion transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	23155
	229725
	ENSG00000121940
	ENSMUSG00000027884
	Q96S66
	Q99LI2
	NM_015127; NM_001048210; NM_001278202; NM_001278203
	NM_001177770; NM_001177771; NM_145543; NM_001355632
NP_001041675; NP_001265131; NP_001265132; NP_055942; NP_001364387;
	NP_001364388; NP_001364389; NP_001364390; NP_001364391; NP_001364392; NP_001364393; NP_001364394; NP_001364395; NP_001364396; NP_001364397; NP_001364398; NP_001364399
	NP_001171241; NP_001171242; NP_663518; NP_001342561
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.^[5]^[6]

The protein encoded by this gene is a chloride channel which is related in sequence to the S. cerevisiae MID-1 stretch-activated channel. CLCC1 is located in the membranes of intracellular compartments including endoplasmic reticulum and the Golgi apparatus. It is highly expressed in the testis and moderately in the spleen, liver, kidney, heart, brain, and lung.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121940 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027884 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ ^a ^b Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I (June 2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121940 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027884 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid11279057-6] Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I (June 2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057.

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