CLCN3

CLCN3
Identifiers
Aliases	CLCN3, CLC3, ClC-3, chloride voltage-gated channel 3, NEDSBA, NEDHYBA
External IDs	OMIM: 600580; MGI: 103555; HomoloGene: 20435; GeneCards: CLCN3; OMA:CLCN3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	169,723,673 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	61,436,334 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; endothelial cell; ; Brodmann area 46; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; postcentral gyrus; ; islet of Langerhans; ; parotid gland; ; right ventricle; ; superior vestibular nucleus;
	Top expressed in
	Rostral migratory stream; ; mammillary body; ; lateral septal nucleus; ; ventromedial nucleus; ; lateral geniculate nucleus; ; lateral hypothalamus; ; cingulate gyrus; ; anterior amygdaloid area; ; paraventricular nucleus of hypothalamus; ; subiculum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; volume-sensitive chloride channel activity; PDZ domain binding; protein homodimerization activity; ion channel activity; protein binding; protein heterodimerization activity; antiporter activity; ATP binding; chloride channel activity; voltage-gated chloride channel activity; solute:proton antiporter activity; chloride ion binding;
Cellular component	integral component of membrane; endosome; late endosome; Golgi apparatus; early endosome membrane; membrane; late endosome membrane; synaptic vesicle; vesicle membrane; Golgi membrane; plasma membrane; transport vesicle membrane; secretory granule; cell surface; early endosome; specific granule; phagocytic vesicle; external side of plasma membrane; cytoplasmic vesicle; integral component of plasma membrane;
Biological process	negative regulation of cell volume; endosomal lumen acidification; ion transport; regulation of anion transmembrane transport; chloride transport; regulation of pH; chloride transmembrane transport; regulation of anion transport; transmembrane transport; transport; synaptic vesicle lumen acidification;
	Sources:Amigo / QuickGO
Orthologs
	1182
	12725
	ENSG00000109572
	ENSMUSG00000004319
	P51790
	P51791
	NM_001243372; NM_001243374; NM_001829; NM_173872
	NM_007711; NM_173873; NM_173874; NM_173876
	NP_001230301; NP_001230303; NP_001820; NP_776297
	NP_031737; NP_776298; NP_776299; NP_776301
	Wikidata
View/Edit Human	View/Edit Mouse

H⁺/Cl⁻ exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109572 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004319 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CLCN3 chloride channel 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109572 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004319 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLCN3 chloride channel 3".

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