CLCN4

CLCN4
Identifiers
Aliases	CLCN4, CLC4, ClC-4, ClC-4A, chloride voltage-gated channel 4, MRX15, MRX49, MRXSRC
External IDs	OMIM: 302910; MGI: 104571; HomoloGene: 68207; GeneCards: CLCN4; OMA:CLCN4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	10,237,660 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	7,300,851 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; postcentral gyrus; ; orbitofrontal cortex; ; biceps brachii; ; corpus epididymis; ; lateral nuclear group of thalamus; ; Skeletal muscle tissue of biceps brachii; ; endothelial cell; ; superior frontal gyrus;
	Top expressed in
	barrel cortex; ; medial geniculate nucleus; ; Rostral migratory stream; ; medial dorsal nucleus; ; inferior colliculi; ; deep cerebellar nuclei; ; Region I of hippocampus proper; ; habenula; ; pontine nuclei; ; globus pallidus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATP binding; chloride channel activity; antiporter activity; voltage-gated chloride channel activity; solute:proton antiporter activity; chloride ion binding;
Cellular component	integral component of membrane; endosome; endosome membrane; early endosome membrane; membrane; late endosome membrane; integral component of plasma membrane; endoplasmic reticulum; endoplasmic reticulum membrane; early endosome; Golgi apparatus; plasma membrane;
Biological process	ion transmembrane transport; ion transport; chloride transmembrane transport; transmembrane transport; chloride transport; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1183
	12727
	ENSG00000073464
	ENSMUSG00000000605
	P51793
	Q61418
	NM_001830; NM_001256944
NM_011334; NM_001302386; NM_001302387; NM_001357102; NM_001357103;
	NM_001357104
	NP_001243873; NP_001821
NP_001289315; NP_001289316; NP_035464; NP_001344031; NP_001344032;
	NP_001344033
	Wikidata
View/Edit Human	View/Edit Mouse

H(+)/Cl(-) exchange transporter 4 is a protein that in humans is encoded by the CLCN4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073464 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000605 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ van Slegtenhorst MA, Bassi MT, Borsani G, Wapenaar MC, Ferrero GB, de Conciliis L, Rugarli EI, Grillo A, Franco B, Zoghbi HY, Ballabio A (Sep 1994). "A gene from the Xp22.3 region shares homology with voltage-gated chloride channels". Hum Mol Genet. 3 (4): 547–52. doi:10.1093/hmg/3.4.547. PMID 8069296.
^ "Entrez Gene: CLCN4 chloride channel 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073464 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000605 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8069296-5] van Slegtenhorst MA, Bassi MT, Borsani G, Wapenaar MC, Ferrero GB, de Conciliis L, Rugarli EI, Grillo A, Franco B, Zoghbi HY, Ballabio A (Sep 1994). "A gene from the Xp22.3 region shares homology with voltage-gated chloride channels". Hum Mol Genet. 3 (4): 547–52. doi:10.1093/hmg/3.4.547. PMID 8069296.

[entrez-6] "Entrez Gene: CLCN4 chloride channel 4".

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