CLCN6

CLCN6
Identifiers
Aliases	CLCN6, CLC-6, chloride voltage-gated channel 6, CONRIBA
External IDs	OMIM: 602726; MGI: 1347049; HomoloGene: 985; GeneCards: CLCN6; OMA:CLCN6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,848,079 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,123,278 bp
RNA expression pattern
	Top expressed in
	right testis; ; right auricle; ; left testis; ; anterior pituitary; ; right hemisphere of cerebellum; ; sural nerve; ; middle temporal gyrus; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	substantia nigra; ; central gray substance of midbrain; ; retinal pigment epithelium; ; supraoptic nucleus; ; primary visual cortex; ; medial vestibular nucleus; ; superior frontal gyrus; ; neural layer of retina; ; nucleus of stria terminalis; ; anterior horn of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ion channel activity; ATP binding; antiporter activity; voltage-gated chloride channel activity; protein binding; chloride transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; lysosomal membrane; endosome; endosome membrane; membrane; intracellular membrane-bounded organelle;
Biological process	cell volume homeostasis; response to mechanical stimulus; chloride transport; ion transmembrane transport; ion transport; signal transduction; regulation of anion transmembrane transport; transmembrane transport; chloride transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	1185
	26372
	ENSG00000011021
	ENSMUSG00000029016
	P51797
	O35454
	NM_001256959; NM_001286; NM_021735; NM_021736; NM_021737
	NM_011929
	NP_001243888; NP_001277
	NP_036059
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.^[5]^[6]

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011021 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029016 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brandt S, Jentsch TJ (Feb 1996). "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family". FEBS Lett. 377 (1): 15–20. doi:10.1016/0014-5793(95)01298-2. PMID 8543009. S2CID 717696.
^ ^a ^b "Entrez Gene: CLCN6 chloride channel 6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000011021 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029016 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8543009-5] Brandt S, Jentsch TJ (Feb 1996). "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family". FEBS Lett. 377 (1): 15–20. doi:10.1016/0014-5793(95)01298-2. PMID 8543009. S2CID 717696.

[entrez-6] "Entrez Gene: CLCN6 chloride channel 6".

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