CLCNKA

CLCNKA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PFI
Identifiers
Aliases	CLCNKA, CLCK1, ClC-K1, hClC-Ka, chloride voltage-gated channel Ka
External IDs	OMIM: 602024; MGI: 1930643; HomoloGene: 107317; GeneCards: CLCNKA; OMA:CLCNKA - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	16,034,050 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	141,143,325 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; pituitary gland; ; anterior pituitary; ; body of pancreas; ; human kidney; ; right adrenal cortex; ; testicle; ; right hemisphere of cerebellum; ; body of stomach;
	Top expressed in
	blastocyst; ; right kidney; ; inner renal medulla; ; human kidney; ; outer renal medulla; ; inner stripe of outer renal medulla; ; submandibular gland; ; connecting tubule; ; distal tubule; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; voltage-gated ion channel activity; chloride channel activity; voltage-gated chloride channel activity; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; chloride channel complex; membrane;
Biological process	ion transmembrane transport; chloride transport; excretion; regulation of ion transmembrane transport; ion transport; transmembrane transport; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1187
	56365
	ENSG00000186510
	ENSMUSG00000006216
	P51800
	Q9WUB6
	NM_004070; NM_001042704; NM_001257139
	NM_019701
	NP_001036169; NP_001244068; NP_004061
	NP_062675
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride channel protein ClC-Ka is a protein that in humans is encoded by the CLCNKA gene. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186510 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006216 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takeuchi Y, Uchida S, Marumo F, Sasaki S (Feb 1996). "Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney". Kidney Int. 48 (5): 1497–503. doi:10.1038/ki.1995.439. PMID 8544406.
^ "Entrez Gene: CLCNKA chloride channel Ka".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186510 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006216 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8544406-5] Takeuchi Y, Uchida S, Marumo F, Sasaki S (Feb 1996). "Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney". Kidney Int. 48 (5): 1497–503. doi:10.1038/ki.1995.439. PMID 8544406.

[entrez-6] "Entrez Gene: CLCNKA chloride channel Ka".

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