CLCNKB

CLCNKB
Identifiers
Aliases	CLCNKB, CLCKB, ClC-K2, ClC-Kb, chloride voltage-gated channel Kb
External IDs	OMIM: 602023; MGI: 1329026; HomoloGene: 65; GeneCards: CLCNKB; OMA:CLCNKB - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	16,057,311 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	141,126,035 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; parotid gland; ; sperm; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; human kidney; ; apex of heart; ; oocyte; ; cerebellar hemisphere; ; right hemisphere of cerebellum;
	Top expressed in
	right kidney; ; distal tubule; ; outer renal medulla; ; human kidney; ; connecting tubule; ; Ascending limb of loop of Henle; ; stria vascularis; ; inner renal medulla; ; inner stripe of outer renal medulla; ; saccule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; voltage-gated ion channel activity; chloride channel activity; voltage-gated chloride channel activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; chloride channel complex; membrane;
Biological process	ion transmembrane transport; chloride transport; excretion; regulation of ion transmembrane transport; ion transport; transmembrane transport; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1188
	12733
	ENSG00000184908
	ENSMUSG00000033770
	P51801
	Q9WUB7
	NM_000085; NM_001165945
	NM_001146307; NM_024412
	NP_000076; NP_001159417
	NP_001139779; NP_077723
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.^[5]^[6]

Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels.^[7] Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome.^[8] CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184908 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033770 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CLCNKB chloride channel Kb".
^ Saito-Ohara F, Uchida S, Takeuchi Y, Sasaki S, Hayashi A, Marumo F, Ikeuchi T (September 1996). "Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization". Genomics. 36 (2): 372–4. doi:10.1006/geno.1996.0479. PMID 8812470.
^ Jentsch TJ, Günther W (February 1997). "Chloride channels: an emerging molecular picture". BioEssays. 19 (2): 117–26. doi:10.1002/bies.950190206. PMID 9046241. S2CID 19904492.
^ Krämer BK, Bergler T, Stoelcker B, Waldegger S (January 2008). "Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance". Nat Clin Pract Nephrol. 4 (1): 38–46. doi:10.1038/ncpneph0689. PMID 18094726. S2CID 25570342.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184908 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033770 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLCNKB chloride channel Kb".

[pmid8812470-6] Saito-Ohara F, Uchida S, Takeuchi Y, Sasaki S, Hayashi A, Marumo F, Ikeuchi T (September 1996). "Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization". Genomics. 36 (2): 372–4. doi:10.1006/geno.1996.0479. PMID 8812470.

[pmid9046241-7] Jentsch TJ, Günther W (February 1997). "Chloride channels: an emerging molecular picture". BioEssays. 19 (2): 117–26. doi:10.1002/bies.950190206. PMID 9046241. S2CID 19904492.

[pmid18094726-8] Krämer BK, Bergler T, Stoelcker B, Waldegger S (January 2008). "Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance". Nat Clin Pract Nephrol. 4 (1): 38–46. doi:10.1038/ncpneph0689. PMID 18094726. S2CID 25570342.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]