CLOCK

CLOCK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H10
Identifiers
Aliases	CLOCK, KAT13D, bHLHe8, clock circadian regulator
External IDs	OMIM: 601851; MGI: 99698; HomoloGene: 3603; GeneCards: CLOCK; OMA:CLOCK - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q12 Start 55,427,903 bp[1] End 55,546,909 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.3|5 40.63 cM Start 76,357,715 bp[2] End 76,452,639 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte germinal epithelium caput epididymis tail of epididymis retinal pigment epithelium testicle tibialis anterior muscle tibia gingival epithelium lower lobe of lung Top expressed in retinal pigment epithelium zygote ciliary body secondary oocyte epithelium of lens conjunctival fornix skin of external ear left colon aorta ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding sequence-specific DNA binding protein dimerization activity DNA-binding transcription factor activity histone acetyltransferase activity RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding E-box binding core promoter sequence-specific DNA binding protein binding chromatin DNA binding acyltransferase activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component cytoplasm chromatoid body intracellular membrane-bounded organelle transcription regulator complex chromosome nucleoplasm nucleus cytosol Biological process negative regulation of glucocorticoid receptor signaling pathway positive regulation of inflammatory response regulation of transcription, DNA-templated photoperiodism regulation of insulin secretion rhythmic process regulation of transcription by RNA polymerase II DNA damage checkpoint signaling regulation of type B pancreatic cell development transcription by RNA polymerase II circadian regulation of gene expression transcription, DNA-templated positive regulation of transcription, DNA-templated response to redox state cellular response to DNA damage stimulus positive regulation of NF-kappaB transcription factor activity circadian rhythm spermatogenesis regulation of hair cycle cellular response to ionizing radiation negative regulation of transcription, DNA-templated signal transduction positive regulation of transcription by RNA polymerase II proteasome-mediated ubiquitin-dependent protein catabolic process histone acetylation protein acetylation regulation of circadian rhythm Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9575 12753 Ensembl ENSG00000134852 ENSMUSG00000029238 UniProt O15516 O08785 RefSeq (mRNA) NM_001267843 NM_004898 NM_007715 NM_001289826 NM_001305222 RefSeq (protein) NP_001254772 NP_004889 NP_001276755 NP_001292151 NP_031741 Location (UCSC) Chr 4: 55.43 – 55.55 Mb Chr 5: 76.36 – 76.45 Mb PubMed search [3] [4]
Wikidata
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CLOCK (backronym for circadian locomotor output cycles kaput) is a gene encoding a basic helix-loop-helix-PAS transcription factor that is known to affect both the persistence and period of circadian rhythms.

Research shows that the CLOCK gene plays a major role as an activator of downstream elements in the pathway critical to the generation of circadian rhythms.^[5][6]