CPSF1

CPSF1
Identifiers
AliasesCPSF1, CPSF160, HSU37012, P/cl.18, cleavage and polyadenylation specific factor 1
External IDsOMIM: 606027; MGI: 2679722; HomoloGene: 40865; GeneCards: CPSF1; OMA:CPSF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013291

NM_001164173
NM_053193
NM_001361485

RefSeq (protein)

NP_037423

NP_001157645
NP_444423
NP_001348414

Location (UCSC)Chr 8: 144.39 – 144.41 MbChr 15: 76.48 – 76.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.[5][6][7]

In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin and WDR33 and located in the nucleus.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000071894Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034022Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jenny A, Keller W (Sep 1995). "Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor". Nucleic Acids Res. 23 (14): 2629–35. doi:10.1093/nar/23.14.2629. PMC 307085. PMID 7651824.
  6. ^ Murthy KG, Manley JL (Dec 1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
  7. ^ "Entrez Gene: CPSF1 cleavage and polyadenylation specific factor 1, 160kDa".
  8. ^ Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR, Frank J, Manley JL (February 2009). "Molecular architecture of the human pre-mRNA 3' processing complex". Mol. Cell. 33 (3): 365–76. doi:10.1016/j.molcel.2008.12.028. PMC 2946185. PMID 19217410.