CRD-BP

The mouse Coding Region Determinant-Binding Protein (CRD-BP) is an RNA-binding protein.[1] CRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ZBP1[1] and the human forms of the protein IMP-1, IMP-2 and IMP-3.[1][2][3] Because of their close relationship, CRD-BP and its orthologs are thought to share the same biochemical properties. Upon binding to its transcripts, CRD-BP plays a role in translation by stabilizing and localizing the transcripts in the cell.[3] Normal expression of CRD-BP has been seen in the early development of the embryo.[3] Conversely, CRD-BP expression in adult tissue is extremely low or completely absent.[4]

  1. ^ a b c Doyle, G., et al. 1998. The c-myc¬ coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. Nuc. Acid. Res. 26:5036-5044.
  2. ^ Liao, B., et al. 2005. The RNA-binding protein IMP-3 is a translational activator of insulin-growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells. The journal of biological chemistry, 280: 18517-18524
  3. ^ a b c Christiansen, J., et al. 2009. IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes. Journal of Molecular Endocrinology, 43:187-195
  4. ^ Prokipcak, R., et al. 1994. Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA. Journal of Biological Chemistry, 12: 9261-9269.