CTGF

CCN2
Identifiers
Aliases	CCN2, HCS24, IGFBP8, NOV2, connective tissue growth factor, cellular communication network factor 2, CTGF
External IDs	OMIM: 121009; MGI: 95537; HomoloGene: 1431; GeneCards: CCN2; OMA:CCN2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.2 Start 131,948,176 bp[1] End 131,951,372 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A4|10 11.84 cM Start 24,471,340 bp[2] End 24,474,581 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia thoracic aorta ascending aorta smooth muscle tissue gastric mucosa right coronary artery gallbladder Descending thoracic aorta left coronary artery tendon of biceps brachii Top expressed in tunica media of zone of aorta stroma of bone marrow ascending aorta semi-lunar valve ankle joint aortic valve skin of external ear ankle ciliary body epithelium of lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibronectin binding insulin-like growth factor binding protein C-terminus binding protein binding growth factor activity integrin binding heparin binding Cellular component cytosol cis-Golgi network plasma membrane extracellular region cell cortex perinuclear region of cytoplasm extracellular space extracellular matrix collagen-containing extracellular matrix Biological process positive regulation of collagen biosynthetic process positive regulation of cell activation cell differentiation regulation of chondrocyte differentiation response to amino acid response to estradiol response to anoxia intracellular signal transduction response to mineralocorticoid response to fatty acid DNA biosynthetic process positive regulation of cell death ossification response to organic cyclic compound extracellular matrix constituent secretion lung development response to peptide hormone positive regulation of G0 to G1 transition positive regulation of JNK cascade response to glucose negative regulation of gene expression reactive oxygen species metabolic process fibroblast growth factor receptor signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of gene expression connective tissue development response to wounding regulation of cell growth angiogenesis tissue homeostasis positive regulation of cell population proliferation chondrocyte proliferation positive regulation of cell differentiation epidermis development positive regulation of cardiac muscle contraction positive regulation of ERK1 and ERK2 cascade positive regulation of protein phosphorylation integrin-mediated signaling pathway transcription initiation from RNA polymerase II promoter cell-matrix adhesion cell migration cartilage condensation positive regulation of stress fiber assembly human ageing cell adhesion cell-cell signaling negative regulation of cell death regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1490 14219 Ensembl ENSG00000118523 ENSMUSG00000019997 UniProt P29279 P29268 RefSeq (mRNA) NM_001901 NM_010217 RefSeq (protein) NP_001892 NP_034347 Location (UCSC) Chr 6: 131.95 – 131.95 Mb Chr 10: 24.47 – 24.47 Mb PubMed search [3] [4]
Wikidata
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CTGF, also known as CCN2 or connective tissue growth factor,^[5][6] is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein).^[7][8][9] CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers.^[5][6][10]