CUL4A

CUL4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HYE, 4A0K
Identifiers
Aliases	CUL4A, cullin 4A
External IDs	OMIM: 603137; MGI: 1914487; HomoloGene: 81724; GeneCards: CUL4A; OMA:CUL4A - orthologs
Gene location (Mouse) Chr. Chromosome 8 (mouse)[1] Band 8|8 A1.1 Start 13,155,621 bp[1] End 13,197,940 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in Ileal epithelium tail of embryo spermatocyte neural layer of retina ascending aorta aortic valve genital tubercle muscle of thigh gastrula ureter BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity ubiquitin protein ligase binding protein binding Cellular component nucleoplasm Cul4-RING E3 ubiquitin ligase complex cullin-RING ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex SCF ubiquitin ligase complex Biological process ubiquitin-dependent protein catabolic process negative regulation of granulocyte differentiation nucleotide-excision repair, DNA damage recognition negative regulation of cell population proliferation positive regulation of G1/S transition of mitotic cell cycle intrinsic apoptotic signaling pathway regulation of protein metabolic process somatic stem cell population maintenance nucleotide-excision repair, DNA incision viral process transcription-coupled nucleotide-excision repair positive regulation of cell population proliferation cellular response to DNA damage stimulus regulation of DNA damage checkpoint global genome nucleotide-excision repair in utero embryonic development regulation of nucleotide-excision repair nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, preincision complex stabilization DNA repair nucleotide-excision repair, preincision complex assembly post-translational protein modification proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination G1/S transition of mitotic cell cycle hemopoiesis SCF-dependent proteasomal ubiquitin-dependent protein catabolic process nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair, DNA incision, 3'-to lesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8451 99375 Ensembl ENSG00000139842 ENSMUSG00000031446 UniProt Q13619 Q3TCH7 RefSeq (mRNA) NM_001008895 NM_001278513 NM_001278514 NM_003589 NM_146207 NM_001363448 NM_001363450 RefSeq (protein) NP_001008895 NP_001265442 NP_001265443 NP_003580 NP_001341867 NP_001341868 NP_001341869 NP_001341870 NP_001341871 NP_001341872 NP_001341873 NP_666319 NP_001350377 NP_001350379 Location (UCSC) n/a Chr 8: 13.16 – 13.2 Mb PubMed search [2] [3]
Wikidata
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Cullin-4A is a protein that in humans is encoded by the CUL4A gene.^[4][5] CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. As a result, CUL4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV. A component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide.