CUL4B

CUL4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO7, 4A0C, 4A0L, 4A64
Identifiers
Aliases	CUL4B, CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2, cullin 4B
External IDs	OMIM: 300304; MGI: 1919834; HomoloGene: 2660; GeneCards: CUL4B; OMA:CUL4B - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq24 Start 120,505,920 bp[1] End 120,604,074 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A3.3 Start 37,622,151 bp[2] End 37,665,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm corpus epididymis tendon of biceps brachii tail of epididymis caput epididymis Achilles tendon ganglionic eminence stromal cell of endometrium ventricular zone superficial temporal artery Top expressed in secondary oocyte zygote tail of embryo epiblast Epithelium of choroid plexus Gonadal ridge primary oocyte genital tubercle mandibular prominence seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity damaged DNA binding protein binding ubiquitin protein ligase binding Cellular component cullin-RING ubiquitin ligase complex nucleoplasm extracellular exosome nucleus cytosol Cul4B-RING E3 ubiquitin ligase complex Cul4-RING E3 ubiquitin ligase complex SCF ubiquitin ligase complex Biological process positive regulation of protein catabolic process nucleotide-excision repair, DNA damage recognition ubiquitin-dependent protein catabolic process histone H2A monoubiquitination cellular response to DNA damage stimulus positive regulation of G1/S transition of mitotic cell cycle global genome nucleotide-excision repair cell cycle transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision neuron projection development UV-damage excision repair nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA duplex unwinding DNA repair nucleotide-excision repair, preincision complex stabilization post-translational protein modification proteasomal protein catabolic process protein ubiquitination G1/S transition of mitotic cell cycle SCF-dependent proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8450 72584 Ensembl ENSG00000158290 ENSMUSG00000031095 UniProt Q13620 A2A432 RefSeq (mRNA) NM_001079872 NM_003588 NM_001330624 NM_001369145 NM_001110142 NM_028288 RefSeq (protein) NP_001073341 NP_001317553 NP_003579 NP_001356074 NP_001103612 NP_082564 Location (UCSC) Chr X: 120.51 – 120.6 Mb Chr X: 37.62 – 37.67 Mb PubMed search [3] [4]
Wikidata
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Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome.^[5][6] CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions. CUL4B is largely expressed in the nucleus and regulates several key functions including: cell cycle progression, chromatin remodeling and neurological and placental development in mice. In humans, CUL4B has been implicated in X-linked intellectual disability and is frequently mutated in pancreatic adenocarcinomas and a small percentage of various lung cancers. Viruses such as HIV can also co-opt CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide.