CX3CL1

CX3CL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B2T, 1F2L, 3ONA, 4XT1, 4XT3
Identifiers
Aliases	CX3CL1, ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin, C-X3-C motif chemokine ligand 1
External IDs	OMIM: 601880; MGI: 1097153; HomoloGene: 2251; GeneCards: CX3CL1; OMA:CX3CL1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,385,044 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,509,055 bp
RNA expression pattern
	Top expressed in
	right lung; ; right coronary artery; ; prefrontal cortex; ; olfactory zone of nasal mucosa; ; frontal pole; ; ascending aorta; ; Descending thoracic aorta; ; right frontal lobe; ; popliteal artery; ; tibial arteries;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; visual cortex; ; primary visual cortex; ; olfactory tubercle; ; superior frontal gyrus; ; primary motor cortex; ; prefrontal cortex; ; nucleus accumbens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; chemokine activity; protein binding; CCR chemokine receptor binding; signaling receptor binding; integrin binding; CX3C chemokine receptor binding;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; cell surface; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; defense response; positive regulation of inflammatory response; monocyte chemotaxis; cytokine-mediated signaling pathway; chemokine-mediated signaling pathway; angiogenesis involved in wound healing; cellular response to tumor necrosis factor; wound healing; leukocyte chemotaxis; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of transforming growth factor beta1 production; positive regulation of GTPase activity; cell adhesion; immune response; cellular response to interleukin-1; leukocyte adhesive activation; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; cell chemotaxis; lymphocyte chemotaxis; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of calcium-independent cell-cell adhesion; chemotaxis; integrin activation; negative regulation of cell migration; leukocyte migration involved in inflammatory response; macrophage chemotaxis; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	6376
	20312
	ENSG00000006210
	ENSMUSG00000031778
	P78423
	O35188
	NM_002996; NM_001304392
	NM_009142
	NP_001291321; NP_002987
	NP_033168
	Wikidata
View/Edit Human	View/Edit Mouse

Fractalkine, also known as chemokine (C-X3-C motif) ligand 1, is a protein that in humans is encoded by the CX3CL1 gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006210 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031778 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006210 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031778 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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