CXCR5

CXCR5
Identifiers
Aliases	CXCR5, BLR1, CD185, MDR15, C-X-C motif chemokine receptor 5, C-X-C chemokine receptor type 5
External IDs	OMIM: 601613; MGI: 103567; HomoloGene: 1298; GeneCards: CXCR5; OMA:CXCR5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,897,787 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,473,174 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; lymph node; ; appendix; ; testicle; ; blood; ; muscle of thigh; ; apex of heart; ; ascending aorta; ; tibial arteries;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; spermatid; ; blood; ; subcutaneous adipose tissue; ; granulocyte; ; spermatocyte; ; lumbar spinal ganglion; ; left lung; ; tunica adventitia of aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C-X-C chemokine receptor activity; G protein-coupled receptor activity; protein binding; signal transducer activity; C-C chemokine receptor activity; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; external side of plasma membrane;
Biological process	positive regulation of cytokinesis; chemokine-mediated signaling pathway; chemotaxis; B cell activation; G protein-coupled receptor signaling pathway; lymph node development; immune response; signal transduction; leukocyte chemotaxis; positive regulation of cytosolic calcium ion concentration; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	643
	12145
	ENSG00000160683
	ENSMUSG00000047880
	P32302
	Q04683
	NM_032966; NM_001716
	NM_007551
	NP_001707; NP_116743
	NP_031577
	Wikidata
View/Edit Human	View/Edit Mouse

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. It enables T cells to migrate to lymph node and the B cell zones. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160683 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047880 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dobner T, Wolf I, Emrich T, Lipp M (November 1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma". European Journal of Immunology. 22 (11): 2795–2799. doi:10.1002/eji.1830221107. PMID 1425907. S2CID 35096818.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160683 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047880 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1425907-5] Dobner T, Wolf I, Emrich T, Lipp M (November 1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma". European Journal of Immunology. 22 (11): 2795–2799. doi:10.1002/eji.1830221107. PMID 1425907. S2CID 35096818.

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