CYP1A1

CYP1A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4I8V
Identifiers
Aliases	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX, CYPIA1, cytochrome P450 family 1 subfamily A member 1
External IDs	OMIM: 108330; MGI: 88588; HomoloGene: 68062; GeneCards: CYP1A1; OMA:CYP1A1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.1 Start 74,719,542 bp[1] End 74,725,536 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 B|9 31.34 cM Start 57,595,211 bp[2] End 57,611,107 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle jejunal mucosa islet of Langerhans trachea right lobe of liver epithelium of colon urinary bladder cartilage tissue skin of leg mucosa of urinary bladder Top expressed in transitional epithelium of urinary bladder lip olfactory epithelium gastrula right lung embryo embryo skin of external ear jejunum skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding flavonoid 3'-monooxygenase activity demethylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen metal ion binding steroid hydroxylase activity catalytic activity protein binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enzyme binding vitamin D 24-hydroxylase activity oxidoreductase activity aromatase activity oxidoreductase activity, acting on diphenols and related substances as donors monooxygenase activity estrogen 16-alpha-hydroxylase activity Hsp70 protein binding Hsp90 protein binding Cellular component cytoplasm organelle membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle membrane endoplasmic reticulum mitochondrion mitochondrial inner membrane Biological process response to immobilization stress maternal process involved in parturition response to hypoxia 9-cis-retinoic acid biosynthetic process response to organic cyclic compound coumarin metabolic process vitamin D metabolic process insecticide metabolic process response to hyperoxia response to antibiotic demethylation cellular response to organic cyclic compound response to virus human ageing hepatocyte differentiation epoxygenase P450 pathway dibenzo-p-dioxin catabolic process response to arsenic-containing substance response to organic substance positive regulation of G1/S transition of mitotic cell cycle response to vitamin A response to lipopolysaccharide omega-hydroxylase P450 pathway response to wounding dibenzo-p-dioxin metabolic process response to nematode response to iron(III) ion flavonoid metabolic process response to food liver development camera-type eye development digestive tract development cell population proliferation response to herbicide porphyrin-containing compound metabolic process ethylene metabolic process lipid hydroxylation steroid metabolic process cellular response to copper ion amine metabolic process toxin metabolic process response to toxic substance regulation of lipid metabolic process heterocycle metabolic process hydrogen peroxide biosynthetic process developmental process long-chain fatty acid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1543 13076 Ensembl ENSG00000140465 ENSMUSG00000032315 UniProt P04798 P00184 RefSeq (mRNA) NM_000499 NM_001319216 NM_001319217 NM_001136059 NM_009992 RefSeq (protein) NP_000490 NP_001306145 NP_001306146 NP_001129531 NP_034122 Location (UCSC) Chr 15: 74.72 – 74.73 Mb Chr 9: 57.6 – 57.61 Mb PubMed search [3] [4]
Wikidata
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Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein^[5] that in humans is encoded by the CYP1A1 gene.^[6] The protein is a member of the cytochrome P450 superfamily of enzymes.^[7]